Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

Mohammad Kurd; Vahid Valipour Dehnou; Seyed A. Tavakoli; Daniel E. Gahreman

doi:10.1111/jdi.12868

Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

Mohammad Kurd, Vahid Valipour Dehnou, Seyed A. Tavakoli, Daniel E. Gahreman

CDU College of Health and Human Sciences

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Abstract

Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats.

Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise(E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method.

Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001).There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001).

Conclusions: The results of this study suggest that the level ofDJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercisecould mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	Journal of Diabetes Investigation
Volume	10
Issue number	1
Early online date	23 May 2018
DOIs	https://doi.org/10.1111/jdi.12868
Publication status	Published - 1 Jan 2019

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title = "Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats",

abstract = "Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats.Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise(E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method.Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001).There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001).Conclusions: The results of this study suggest that the level ofDJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercisecould mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.",

keywords = "Metabolic syndrome, Neurodegenerative diseases, Physical activity",

author = "Mohammad Kurd and {Valipour Dehnou}, Vahid and Tavakoli, {Seyed A.} and Gahreman, {Daniel E.}",

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AU - Kurd, Mohammad

AU - Valipour Dehnou, Vahid

AU - Tavakoli, Seyed A.

AU - Gahreman, Daniel E.

PY - 2019/1/1

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N2 - Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats.Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise(E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method.Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001).There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001).Conclusions: The results of this study suggest that the level ofDJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercisecould mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

AB - Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats.Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise(E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method.Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001).There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001).Conclusions: The results of this study suggest that the level ofDJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercisecould mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

KW - Metabolic syndrome

KW - Neurodegenerative diseases

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Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

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