Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

Mohammad Kurd, Vahid Valipour Dehnou, Seyed A. Tavakoli, Daniel E. Gahreman

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats.


Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method.


Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001).


Conclusions: The results of this study suggest that the level of DJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

LanguageEnglish
Pages43-50
Number of pages8
JournalJournal of Diabetes Investigation
Volume10
Issue number1
Early online date23 May 2018
DOIs
StatePublished - 1 Jan 2019

Fingerprint

Cannabinoid Receptors
Blood Glucose
Hippocampus
Cannabinoid Receptor CB2
Immunosorbents
Glucose
Control Groups
Proteins

Cite this

@article{1615d17d364b4c9aa27743c43d420987,
title = "Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats",
abstract = "Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats. Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method. Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001). Conclusions: The results of this study suggest that the level of DJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.",
keywords = "Metabolic syndrome, Neurodegenerative diseases, Physical activity",
author = "Mohammad Kurd and {Valipour Dehnou}, Vahid and Tavakoli, {Seyed A.} and Gahreman, {Daniel E.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jdi.12868",
language = "English",
volume = "10",
pages = "43--50",
journal = "Journal of Diabetes Investigation",
issn = "2040-1116",
publisher = "Blackwell Publishing Asia Pty Ltd",
number = "1",

}

Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats. / Kurd, Mohammad; Valipour Dehnou, Vahid; Tavakoli, Seyed A.; Gahreman, Daniel E.

In: Journal of Diabetes Investigation, Vol. 10, No. 1, 01.01.2019, p. 43-50.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

AU - Kurd,Mohammad

AU - Valipour Dehnou,Vahid

AU - Tavakoli,Seyed A.

AU - Gahreman,Daniel E.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats. Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method. Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001). Conclusions: The results of this study suggest that the level of DJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

AB - Aims/Introduction: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats. Materials and Methods: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB2 were measured using an enzyme‐linked immunosorbent assay method. Results: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB2 and blood glucose (r = −0.77, P ≤ 0.001). Conclusions: The results of this study suggest that the level of DJ‐1 and CB2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB2 on diabetes‐induced neurodegenerative diseases.

KW - Metabolic syndrome

KW - Neurodegenerative diseases

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=85059503366&partnerID=8YFLogxK

U2 - 10.1111/jdi.12868

DO - 10.1111/jdi.12868

M3 - Article

VL - 10

SP - 43

EP - 50

JO - Journal of Diabetes Investigation

T2 - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

SN - 2040-1116

IS - 1

ER -