Efficacy of Single-Dose Primaquine with Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

Kasia Stepniewska, Georgina S. Humphreys, Bronner P. Gonçalves, Elaine Craig, Roly Gosling, Philippe J. Guerin, Ric N. Price, Karen I. Barnes, Jaishree Raman, Menno R. Smit, Umberto D'Alessandro, Will J.R. Stone, Anders Bjorkman, Aaron M. Samuels, Maria I. Arroyo-Arroyo, Guido J.H. Bastiaens, Joelle M. Brown, Alassane Dicko, Badria B. El-Sayed, Salah Eldin G. ElzakiAlice C. Eziefula, Simon Kariuki, Titus K. Kwambai, Amanda E. Maestre, Andreas Martensson, Dominic Mosha, Richard O. Mwaiswelo, Billy E. Ngasala, Joseph Okebe, Michelle E. Roh, Patrick Sawa, Alfred B. Tiono, Ingrid Chen, Chris J. Drakeley, Teun Bousema

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to assess efficacy. Methods: An individual patient meta-Analysis to assess gametocytocidal and transmission-blocking efficacy of PQ in combination with different ACTs was conducted. Random effects logistic regression was used to quantify PQ effect on (1) gametocyte carriage in the first 2 weeks post treatment; and (2) the probability of infecting at least 1 mosquito or of a mosquito becoming infected. Results: In 2574 participants from 14 studies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients presenting with gametocytemia on day 0 (odds ratio [OR],0.22; 95% confidence interval [CI],. 17-.28 and OR,0.12; 95% CI,. 08-.16, respectively). Rate of decline in gametocyte carriage was faster when PQ was combined with artemether-lumefantrine (AL) compared to dihydroartemisinin-piperaquine (DP) (P=.010 for day 7). Addition of 0.25 mg/kg PQ was associated with near complete prevention of transmission to mosquitoes. Conclusions: Transmission blocking is achieved with 0.25 mg/kg PQ. Gametocyte persistence and infectivity are lower when PQ is combined with AL compared to DP.

    Original languageEnglish
    Pages (from-to)1215-1226
    Number of pages12
    JournalJournal of Infectious Diseases
    Volume225
    Issue number7
    DOIs
    Publication statusPublished - 1 Apr 2022

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