Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides

Shi Qi Zhang; Yao Cui; Bin Guo; David J. Young; Ze Xu; Hong Xi Li

doi:10.1016/j.tet.2020.131825

Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides

Shi Qi Zhang, Yao Cui, Bin Guo, David J. Young, Ze Xu, Hong Xi Li

Research output: Contribution to journal › Article › peer-review

Abstract

The acceptorless dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl₂·4H₂O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

Original language	English
Article number	131825
Pages (from-to)	1-8
Number of pages	8
Journal	Tetrahedron
Volume	78
DOIs	https://doi.org/10.1016/j.tet.2020.131825
Publication status	Published - 8 Jan 2021

Access to Document

10.1016/j.tet.2020.131825

Cite this

@article{aedab05e99344569a1bf2cba8688e6ff,

title = "Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides",

abstract = "The acceptorless dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.",

keywords = "Acceptorless dehydrogenative coupling, Iron catalyst, Mild conditions, Phosphine-free, Quinazoline",

author = "Zhang, {Shi Qi} and Yao Cui and Bin Guo and Young, {David J.} and Ze Xu and Li, {Hong Xi}",

year = "2021",

month = jan,

day = "8",

doi = "10.1016/j.tet.2020.131825",

language = "English",

volume = "78",

pages = "1--8",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier",

}

TY - JOUR

T1 - Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides

AU - Zhang, Shi Qi

AU - Cui, Yao

AU - Guo, Bin

AU - Young, David J.

AU - Xu, Ze

AU - Li, Hong Xi

PY - 2021/1/8

Y1 - 2021/1/8

N2 - The acceptorless dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

AB - The acceptorless dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

KW - Acceptorless dehydrogenative coupling

KW - Iron catalyst

KW - Mild conditions

KW - Phosphine-free

KW - Quinazoline

UR - http://www.scopus.com/inward/record.url?scp=85097457082&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2020.131825

DO - 10.1016/j.tet.2020.131825

M3 - Article

AN - SCOPUS:85097457082

SN - 0040-4020

VL - 78

SP - 1

EP - 8

JO - Tetrahedron

JF - Tetrahedron

M1 - 131825

ER -

Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides

Abstract

Access to Document

Other files and links

Fingerprint

Cite this