Emergence of Burkholderia pseudomallei sequence type 562, Northern Australia

Ella M. Meumann; Mirjam Kaestli; Mark Mayo; Linda Ward; Audrey Rachlin; Jessica R. Webb; Mariana Kleinecke; Erin P. Price; Bart J. Currie

doi:10.3201/eid2704.202716

Emergence of Burkholderia pseudomallei sequence type 562, Northern Australia

Ella M. Meumann, Mirjam Kaestli, Mark Mayo, Linda Ward, Audrey Rachlin, Jessica R. Webb, Mariana Kleinecke, Erin P. Price, Bart J. Currie

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.

Original language	English
Pages (from-to)	1057-1067
Number of pages	11
Journal	Emerging Infectious Diseases
Volume	27
Issue number	4
DOIs	https://doi.org/10.3201/eid2704.202716
Publication status	Published - Apr 2021

Bibliographical note

Funding Information:
This research was funded by the Australian National Health and Medical Research Council (grant nos. 1046812, 1098337, and 1131932 [The HOT NORTH initiative]). E.M.M. was funded by a postgraduate scholarship from the Australian National Health and Medical Research Council (grant no. 1114696). E.P.P. was funded by an Advance Queensland fellowship (grant no. AQIRF0362018).

Publisher Copyright:
© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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title = "Emergence of Burkholderia pseudomallei sequence type 562, Northern Australia",

abstract = "Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.",

author = "Meumann, {Ella M.} and Mirjam Kaestli and Mark Mayo and Linda Ward and Audrey Rachlin and Webb, {Jessica R.} and Mariana Kleinecke and Price, {Erin P.} and Currie, {Bart J.}",

note = "Funding Information: This research was funded by the Australian National Health and Medical Research Council (grant nos. 1046812, 1098337, and 1131932 [The HOT NORTH initiative]). E.M.M. was funded by a postgraduate scholarship from the Australian National Health and Medical Research Council (grant no. 1114696). E.P.P. was funded by an Advance Queensland fellowship (grant no. AQIRF0362018). Publisher Copyright: {\textcopyright} 2021 Centers for Disease Control and Prevention (CDC). All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.3201/eid2704.202716",

language = "English",

volume = "27",

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AU - Webb, Jessica R.

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AU - Price, Erin P.

AU - Currie, Bart J.

N1 - Funding Information: This research was funded by the Australian National Health and Medical Research Council (grant nos. 1046812, 1098337, and 1131932 [The HOT NORTH initiative]). E.M.M. was funded by a postgraduate scholarship from the Australian National Health and Medical Research Council (grant no. 1114696). E.P.P. was funded by an Advance Queensland fellowship (grant no. AQIRF0362018). Publisher Copyright: © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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Emergence of Burkholderia pseudomallei sequence type 562, Northern Australia

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