TY - JOUR
T1 - Emergence of Burkholderia pseudomallei sequence type 562, Northern Australia
AU - Meumann, Ella M.
AU - Kaestli, Mirjam
AU - Mayo, Mark
AU - Ward, Linda
AU - Rachlin, Audrey
AU - Webb, Jessica R.
AU - Kleinecke, Mariana
AU - Price, Erin P.
AU - Currie, Bart J.
N1 - Funding Information:
This research was funded by the Australian National Health and Medical Research Council (grant nos. 1046812, 1098337, and 1131932 [The HOT NORTH initiative]). E.M.M. was funded by a postgraduate scholarship from the Australian National Health and Medical Research Council (grant no. 1114696). E.P.P. was funded by an Advance Queensland fellowship (grant no. AQIRF0362018).
Publisher Copyright:
© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.
AB - Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.
UR - http://www.scopus.com/inward/record.url?scp=85103205025&partnerID=8YFLogxK
U2 - 10.3201/eid2704.202716
DO - 10.3201/eid2704.202716
M3 - Article
C2 - 33754984
AN - SCOPUS:85103205025
SN - 1080-6040
VL - 27
SP - 1057
EP - 1067
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 4
ER -