Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes

Hannah E. O’Farrell, Hing Cheong Kok, Suhani Goel, Anne B. Chang, Stephanie T. Yerkovich

Research output: Contribution to journalReview articlepeer-review

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Abstract

Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children.

Original languageEnglish
Article number756
Pages (from-to)1-16
Number of pages16
JournalJournal of Clinical Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - Feb 2024

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