Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India

Protocol for a systematic review and meta-analyses

Madurantakam Royam Madhav, Sankaranarayanan Gomathi Nayagam, Krishnav Biyani, Venkatesh Pandey, Duraj Gowtham Kamal, Shanthi Sabarimurugan, Nachimuthu Ramesh, Kodiveri Muthukaliannan Gothandam, Rama Jayaraj

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Abstract

Background: Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC. The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the incidence, prevalence, and mortality of BC in 29 states and seven union territories of India.

Methods: Data sources used will be Cochrane Review, MEDLINE, PubMed, Scopus, Science Direct, Web of Science, and international and national cancer registries such as World Health Organization, International Agency for Research on Cancer (IARC), and National Centre for Disease Information and Research (NCDIR)-National Cancer Registry Program initiated by Indian Council of Medical Research. Relevant data will be extracted using a predefined data collection form. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. Odds ratios (ORs) will be used to measure effect size. The random or fixed-effects meta-analyses model will be employed to aggregate the pooled estimates (ORs) with 95% confidence intervals (CIs) separately. A forest plot will be produced to assess ORs and 95% CIs. Publication bias will be assessed using funnel plot, and Egger regression will be applied to test the symmetry of the funnel plot.

Ethics and dissemination: This proposed study will be based on published studies and the data from cancer registries. Therefore, human research ethics approval is not required. The results of this study will be published in a peer-reviewed journal.

PROSPERO registration no: CRD42018084003.

Original languageEnglish
Article numbere13680
Pages (from-to)1-6
Number of pages6
JournalMedicine
Volume97
Issue number52
DOIs
Publication statusPublished - 1 Dec 2018

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Meta-Analysis
India
Breast Neoplasms
Registries
Mortality
Odds Ratio
Incidence
Neoplasms
Confidence Intervals
Research Ethics
International Agencies
Information Centers
Publication Bias
Information Storage and Retrieval
Research
PubMed
Ethics
MEDLINE
Patient Selection
Biomedical Research

Cite this

Madhav, M. R., Nayagam, S. G., Biyani, K., Pandey, V., Kamal, D. G., Sabarimurugan, S., ... Jayaraj, R. (2018). Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India: Protocol for a systematic review and meta-analyses. Medicine, 97(52), 1-6. [e13680]. https://doi.org/10.1097/MD.0000000000013680
Madhav, Madurantakam Royam ; Nayagam, Sankaranarayanan Gomathi ; Biyani, Krishnav ; Pandey, Venkatesh ; Kamal, Duraj Gowtham ; Sabarimurugan, Shanthi ; Ramesh, Nachimuthu ; Gothandam, Kodiveri Muthukaliannan ; Jayaraj, Rama. / Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India : Protocol for a systematic review and meta-analyses. In: Medicine. 2018 ; Vol. 97, No. 52. pp. 1-6.
@article{30a6933ed76047d1962fd95589ee0a0c,
title = "Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India: Protocol for a systematic review and meta-analyses",
abstract = "Background: Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC. The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the incidence, prevalence, and mortality of BC in 29 states and seven union territories of India. Methods: Data sources used will be Cochrane Review, MEDLINE, PubMed, Scopus, Science Direct, Web of Science, and international and national cancer registries such as World Health Organization, International Agency for Research on Cancer (IARC), and National Centre for Disease Information and Research (NCDIR)-National Cancer Registry Program initiated by Indian Council of Medical Research. Relevant data will be extracted using a predefined data collection form. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. Odds ratios (ORs) will be used to measure effect size. The random or fixed-effects meta-analyses model will be employed to aggregate the pooled estimates (ORs) with 95{\%} confidence intervals (CIs) separately. A forest plot will be produced to assess ORs and 95{\%} CIs. Publication bias will be assessed using funnel plot, and Egger regression will be applied to test the symmetry of the funnel plot. Ethics and dissemination: This proposed study will be based on published studies and the data from cancer registries. Therefore, human research ethics approval is not required. The results of this study will be published in a peer-reviewed journal. PROSPERO registration no: CRD42018084003.",
author = "Madhav, {Madurantakam Royam} and Nayagam, {Sankaranarayanan Gomathi} and Krishnav Biyani and Venkatesh Pandey and Kamal, {Duraj Gowtham} and Shanthi Sabarimurugan and Nachimuthu Ramesh and Gothandam, {Kodiveri Muthukaliannan} and Rama Jayaraj",
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Madhav, MR, Nayagam, SG, Biyani, K, Pandey, V, Kamal, DG, Sabarimurugan, S, Ramesh, N, Gothandam, KM & Jayaraj, R 2018, 'Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India: Protocol for a systematic review and meta-analyses', Medicine, vol. 97, no. 52, e13680, pp. 1-6. https://doi.org/10.1097/MD.0000000000013680

Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India : Protocol for a systematic review and meta-analyses. / Madhav, Madurantakam Royam; Nayagam, Sankaranarayanan Gomathi; Biyani, Krishnav; Pandey, Venkatesh; Kamal, Duraj Gowtham; Sabarimurugan, Shanthi; Ramesh, Nachimuthu; Gothandam, Kodiveri Muthukaliannan; Jayaraj, Rama.

In: Medicine, Vol. 97, No. 52, e13680, 01.12.2018, p. 1-6.

Research output: Contribution to journalComment/debateResearchpeer-review

TY - JOUR

T1 - Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India

T2 - Protocol for a systematic review and meta-analyses

AU - Madhav, Madurantakam Royam

AU - Nayagam, Sankaranarayanan Gomathi

AU - Biyani, Krishnav

AU - Pandey, Venkatesh

AU - Kamal, Duraj Gowtham

AU - Sabarimurugan, Shanthi

AU - Ramesh, Nachimuthu

AU - Gothandam, Kodiveri Muthukaliannan

AU - Jayaraj, Rama

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC. The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the incidence, prevalence, and mortality of BC in 29 states and seven union territories of India. Methods: Data sources used will be Cochrane Review, MEDLINE, PubMed, Scopus, Science Direct, Web of Science, and international and national cancer registries such as World Health Organization, International Agency for Research on Cancer (IARC), and National Centre for Disease Information and Research (NCDIR)-National Cancer Registry Program initiated by Indian Council of Medical Research. Relevant data will be extracted using a predefined data collection form. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. Odds ratios (ORs) will be used to measure effect size. The random or fixed-effects meta-analyses model will be employed to aggregate the pooled estimates (ORs) with 95% confidence intervals (CIs) separately. A forest plot will be produced to assess ORs and 95% CIs. Publication bias will be assessed using funnel plot, and Egger regression will be applied to test the symmetry of the funnel plot. Ethics and dissemination: This proposed study will be based on published studies and the data from cancer registries. Therefore, human research ethics approval is not required. The results of this study will be published in a peer-reviewed journal. PROSPERO registration no: CRD42018084003.

AB - Background: Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC. The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the incidence, prevalence, and mortality of BC in 29 states and seven union territories of India. Methods: Data sources used will be Cochrane Review, MEDLINE, PubMed, Scopus, Science Direct, Web of Science, and international and national cancer registries such as World Health Organization, International Agency for Research on Cancer (IARC), and National Centre for Disease Information and Research (NCDIR)-National Cancer Registry Program initiated by Indian Council of Medical Research. Relevant data will be extracted using a predefined data collection form. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. Odds ratios (ORs) will be used to measure effect size. The random or fixed-effects meta-analyses model will be employed to aggregate the pooled estimates (ORs) with 95% confidence intervals (CIs) separately. A forest plot will be produced to assess ORs and 95% CIs. Publication bias will be assessed using funnel plot, and Egger regression will be applied to test the symmetry of the funnel plot. Ethics and dissemination: This proposed study will be based on published studies and the data from cancer registries. Therefore, human research ethics approval is not required. The results of this study will be published in a peer-reviewed journal. PROSPERO registration no: CRD42018084003.

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U2 - 10.1097/MD.0000000000013680

DO - 10.1097/MD.0000000000013680

M3 - Comment/debate

VL - 97

SP - 1

EP - 6

JO - Medicine

JF - Medicine

SN - 0025-7974

IS - 52

M1 - e13680

ER -