Epidemiology of intussusception before and after rotavirus vaccine introduction in Fiji

Felisita Tupou Ratu, Rita Reyburn, Evelyn Tuivaga, Asena Tuiketei, Kylie Jenkins, Kim Mulholland, Adam Jenney, Fiona Russell

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    Abstract

    In 2012, Fiji introduced rotavirus vaccine (Rotarix, GSK) into the national immunisation schedule. We describe the intussusception epidemiology prior to rotavirus vaccine, temporal association of intussusception cases to administration of rotavirus vaccine, and estimate the additional number of intussusception cases that may be associated with rotavirus vaccine. A retrospective review of intussusception cases for children aged <24 months old was undertaken between January 2007 and October 2012 pre-vaccine. All admissions and deaths with a discharge diagnosis of intussusception, bowel obstruction, paralytic ileus, or intussusception ICD10-AM codes were extracted from national databases and hospital records. Nationwide active intussusception surveillance was established for three years post-vaccine (2013–2015). There were 24 definite intussusception cases in the pre-rotavirus vaccine period, 96% were confirmed by surgery. The median age was 6.5 months. The incidence rate was 22.2 (95% CI: 13.9–33.7) per 100,000 infants. There were no deaths. Active surveillance identified 25 definite intussusception cases, 96% of which were among children who were age-eligible for rotavirus vaccine. None were potentially vaccine related. We estimated one to five additional cases of intussusception every five years. The incidence of intussusception pre-rotavirus vaccine in Fiji is low. Intussusception associated with rotavirus vaccine is likely a rare event in Fiji.

    Original languageEnglish
    Article number11194
    Pages (from-to)1-6
    Number of pages6
    JournalScientific Reports
    Volume8
    Issue number1
    Early online date25 Jul 2018
    DOIs
    Publication statusPublished - 1 Dec 2018

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    Ratu, F. T., Reyburn, R., Tuivaga, E., Tuiketei, A., Jenkins, K., Mulholland, K., Jenney, A., & Russell, F. (2018). Epidemiology of intussusception before and after rotavirus vaccine introduction in Fiji. Scientific Reports, 8(1), 1-6. [11194]. https://doi.org/10.1038/s41598-018-29515-2