Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report

Anne B. Chang; John Oppenheimer; Miles Weinberger; Cameron C. Grant; Bruce K. Rubin; Richard S. Irwin; Kenneth W. Altman; Elie Azoulay; Alan F. Barker; Surinder S. Birring; Fiona Blackhall; Donald C. Bolser; hristopher Brightling; Priscilla Callahan-Lyon; Paul Davenport; Satoru Ebihara; Ali A. El Solh; Patricio Escalante; Stephen K. Field; Dina Fisher; Cynthia T. French; Susan M. Harding; Peter Gibson; Philip Gold; Anthony Harnden; Adam T. Hill; Richard S. Irwin; Joanne Kavanagh; Karina A. Keogh; Kefang Lai; Andrew P. Lane; J. Mark Madison; Mark A. Malesker; Stuart Mazzone; Alex Molassoitis; M. Hassan Murad; Mangala Narasimhan; Huong Q. Nguyen; Peter Newcombe; John Oppenheimer; Marcos I. Restrepo; Mark Rosen; Bruce Rubin; Jay H. Ryu; Susan M. Tarlo; Julie Turmel; Anne E. Vertigan; Miles Weinberger; Kelly Weir

doi:10.1016/j.chest.2017.06.006

Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report

Anne B. Chang, John Oppenheimer, Miles Weinberger, Cameron C. Grant, Bruce K. Rubin, Richard S. Irwin, Kenneth W. Altman, Elie Azoulay, Alan F. Barker, Surinder S. Birring, Fiona Blackhall, Donald C. Bolser, hristopher Brightling, Priscilla Callahan-Lyon, Paul Davenport, Satoru Ebihara, Ali A. El Solh, Patricio Escalante, Stephen K. Field, Dina FisherCynthia T. French, Susan M. Harding, Peter Gibson, Philip Gold, Anthony Harnden, Adam T. Hill, Richard S. Irwin, Joanne Kavanagh, Karina A. Keogh, Kefang Lai, Andrew P. Lane, J. Mark Madison, Mark A. Malesker, Stuart Mazzone, Alex Molassoitis, M. Hassan Murad, Mangala Narasimhan, Huong Q. Nguyen, Peter Newcombe, John Oppenheimer, Marcos I. Restrepo, Mark Rosen, Bruce Rubin, Jay H. Ryu, Susan M. Tarlo, Julie Turmel, Anne E. Vertigan, Miles Weinberger, Kelly Weir

Child and Maternal Health

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Background: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children?

Methods: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus.

Results: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies.

Conclusions: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

Original language	English
Pages (from-to)	607-617
Number of pages	11
Journal	Chest
Volume	152
Issue number	3
DOIs	https://doi.org/10.1016/j.chest.2017.06.006
Publication status	Published - 1 Sept 2017

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Chang, A. B., Oppenheimer, J., Weinberger, M., Grant, C. C., Rubin, B. K., Irwin, R. S., Altman, K. W., Azoulay, E., Barker, A. F., Birring, S. S., Blackhall, F., Bolser, D. C., Brightling, H., Callahan-Lyon, P., Davenport, P., Ebihara, S., El Solh, A. A., Escalante, P., Field, S. K., ... Weir, K. (2017). Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report. Chest, 152(3), 607-617. https://doi.org/10.1016/j.chest.2017.06.006

@article{12f3ad6491dd4ab48c6f69f7f412e316,

title = "Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report",

abstract = "Background: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients{\textquoteright} values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.",

keywords = "cough, evidence-based medicine, pediatrics",

author = "Chang, {Anne B.} and John Oppenheimer and Miles Weinberger and Grant, {Cameron C.} and Rubin, {Bruce K.} and Irwin, {Richard S.} and Altman, {Kenneth W.} and Elie Azoulay and Barker, {Alan F.} and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and hristopher Brightling and Priscilla Callahan-Lyon and Paul Davenport and Satoru Ebihara and {El Solh}, {Ali A.} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Harding, {Susan M.} and Peter Gibson and Philip Gold and Anthony Harnden and Hill, {Adam T.} and Irwin, {Richard S.} and Joanne Kavanagh and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Madison, {J. Mark} and Malesker, {Mark A.} and Stuart Mazzone and Alex Molassoitis and Murad, {M. Hassan} and Mangala Narasimhan and Nguyen, {Huong Q.} and Peter Newcombe and John Oppenheimer and Restrepo, {Marcos I.} and Mark Rosen and Bruce Rubin and Ryu, {Jay H.} and Tarlo, {Susan M.} and Julie Turmel and Vertigan, {Anne E.} and Miles Weinberger and Kelly Weir",

year = "2017",

month = sep,

day = "1",

doi = "10.1016/j.chest.2017.06.006",

language = "English",

volume = "152",

pages = "607--617",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "3",

}

Chang, AB, Oppenheimer, J, Weinberger, M, Grant, CC, Rubin, BK, Irwin, RS, Altman, KW, Azoulay, E, Barker, AF, Birring, SS, Blackhall, F, Bolser, DC, Brightling, H, Callahan-Lyon, P, Davenport, P, Ebihara, S, El Solh, AA, Escalante, P, Field, SK, Fisher, D, French, CT, Harding, SM, Gibson, P, Gold, P, Harnden, A, Hill, AT, Irwin, RS, Kavanagh, J, Keogh, KA, Lai, K, Lane, AP, Madison, JM, Malesker, MA, Mazzone, S, Molassoitis, A, Murad, MH, Narasimhan, M, Nguyen, HQ, Newcombe, P, Oppenheimer, J, Restrepo, MI, Rosen, M, Rubin, B, Ryu, JH, Tarlo, SM, Turmel, J, Vertigan, AE, Weinberger, M & Weir, K 2017, 'Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report', Chest, vol. 152, no. 3, pp. 607-617. https://doi.org/10.1016/j.chest.2017.06.006

TY - JOUR

T1 - Etiologies of Chronic Cough in Pediatric Cohorts

T2 - CHEST Guideline and Expert Panel Report

AU - Chang, Anne B.

AU - Oppenheimer, John

AU - Weinberger, Miles

AU - Grant, Cameron C.

AU - Rubin, Bruce K.

AU - Irwin, Richard S.

AU - Altman, Kenneth W.

AU - Azoulay, Elie

AU - Barker, Alan F.

AU - Birring, Surinder S.

AU - Blackhall, Fiona

AU - Bolser, Donald C.

AU - Brightling, hristopher

AU - Callahan-Lyon, Priscilla

AU - Davenport, Paul

AU - Ebihara, Satoru

AU - El Solh, Ali A.

AU - Escalante, Patricio

AU - Field, Stephen K.

AU - Fisher, Dina

AU - French, Cynthia T.

AU - Harding, Susan M.

AU - Gibson, Peter

AU - Gold, Philip

AU - Harnden, Anthony

AU - Hill, Adam T.

AU - Irwin, Richard S.

AU - Kavanagh, Joanne

AU - Keogh, Karina A.

AU - Lai, Kefang

AU - Lane, Andrew P.

AU - Madison, J. Mark

AU - Malesker, Mark A.

AU - Mazzone, Stuart

AU - Molassoitis, Alex

AU - Murad, M. Hassan

AU - Narasimhan, Mangala

AU - Nguyen, Huong Q.

AU - Newcombe, Peter

AU - Oppenheimer, John

AU - Restrepo, Marcos I.

AU - Rosen, Mark

AU - Rubin, Bruce

AU - Ryu, Jay H.

AU - Tarlo, Susan M.

AU - Turmel, Julie

AU - Vertigan, Anne E.

AU - Weinberger, Miles

AU - Weir, Kelly

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

AB - Background: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

KW - cough

KW - evidence-based medicine

KW - pediatrics

UR - http://www.scopus.com/inward/record.url?scp=85028984544&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2017.06.006

DO - 10.1016/j.chest.2017.06.006

M3 - Article

C2 - 28645463

AN - SCOPUS:85028984544

SN - 0012-3692

VL - 152

SP - 607

EP - 617

JO - Chest

JF - Chest

IS - 3

ER -

Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report

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