Evidence of a Major Reservoir of Non-Malarial Febrile Diseases in Malaria-Endemic Regions of Bangladesh

Paul Swoboda, Hans-Peter Fuehrer, Benedikt Ley, Peter Starzengruber, Kamala Ley-Thriemer, Mariella Jung, Julia Matt, Markus Fally, Milena Mueller, Johannes Reismann, Rashidul Haque, Wasif Khan, Harald Noedl

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    In malaria-endemic regions any febrile case is likely to be classified as malaria based on presumptive diagnosis largely caused by a lack of diagnostic resources. A district-wide prevalence study assessing etiologies of fever in 659 patients recruited in rural and semi-urban areas of Bandarban district in southeastern Bangladesh revealed high proportions of seropositivity for selected infectious diseases (leptospirosis, typhoid fever) potentially being misdiagnosed as malaria because of similarities in the clinical presentation. In an area with point prevalences of more than 40% for malaria among fever cases, even higher seroprevalence rates of leptospirosis and typhoid fever provide evidence of a major persistent reservoir of these pathogens.
    Original languageEnglish
    Pages (from-to)377-382
    Number of pages6
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Issue number2
    Publication statusPublished - 2014


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