Experimentally induced blood stage malaria infection as a tool for clinical research

Christian Engwerda, Gabriela Minigo, Fiona Amante, James McCarthy

Research output: Contribution to journalArticlepeer-review


A system for experimentally induced blood stage malaria infection (IBSM) with Plasmodium falciparum by direct intravenous inoculation of infected erythrocytes was developed at the Queensland Institute of Medical Research (QIMR) more than 15 years ago. Since that time, this system has been used in several studies to investigate the protective effect of vaccines, the clearance kinetics of parasites following drug treatment, and to improve understanding of the early events in blood stage infection. In this article, we will review the development of IBSM and the applications for which it is being employed. We will discuss the advantages and disadvantages of IBSM, and finish by describing some exciting new areas of research that have been made possible by this system.
Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalTrends in Parasitology
Issue number11
Publication statusPublished - Nov 2012


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