Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

Carina M. Hall, Nawarat Somprasong, Johannah P. Hagen, Roxanne Nottingham, Jason W. Sahl, Jessica R. Webb, Mark Mayo, Bart J. Currie, Yuwana Podin, David M. Wagner, Paul Keim, Herbert P. Schweizer

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Abstract

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by b-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.

Original languageEnglish
Pages (from-to)e00171-23
Number of pages1
JournalAntimicrobial Agents and Chemotherapy
Volume67
Issue number6
Early online date3 May 2023
DOIs
Publication statusPublished - Jun 2023

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