Abstract
Individual patient response to effective therapies for pulmonary hypertension (PAH) is variable and difficult to quantify. Consequently, management decisions regarding initiation and continuation of therapy are highly dependent on the results of investigations. Registry data show that changes in cardiac index, mean right atrial pressure, and mean pulmonary artery pressure have the greatest influence on survival. It is recognized that pulmonary artery pressure (PASP) responses to PAH-specific drugs are heterogeneous. However, follow-up testing is strongly focused on assessing changes in PASP and functional status (6-min walk). The goals of therapy, which should be highlighted in follow-up imaging, include not only reduction of PASP, decrease in pulmonary vascular resistance, and improvements in right ventricular function, cardiac output, and tricuspid regurgitation. This paper reviews the echocardiographic follow-up of pulmonary hypertension, and especially focuses on right ventricular function—a major determinant of outcome, for which reliable echocardiographic assessment has become more feasible.
| Original language | English |
|---|---|
| Pages (from-to) | 733-746 |
| Number of pages | 14 |
| Journal | JACC: Cardiovascular Imaging |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 |
Fingerprint
Cite this
}
Follow-Up of Pulmonary Hypertension With Echocardiography. / Wright, Leah M.; Dwyer, Nathan; Celermajer, David; Kritharides, Len; Marwick, Thomas H.
In: JACC: Cardiovascular Imaging, Vol. 9, No. 6, 2016, p. 733-746.Research output: Contribution to journal › Editorial › Research › peer-review
TY - JOUR
T1 - Follow-Up of Pulmonary Hypertension With Echocardiography
AU - Wright, Leah M.
AU - Dwyer, Nathan
AU - Celermajer, David
AU - Kritharides, Len
AU - Marwick, Thomas H.
PY - 2016
Y1 - 2016
N2 - Individual patient response to effective therapies for pulmonary hypertension (PAH) is variable and difficult to quantify. Consequently, management decisions regarding initiation and continuation of therapy are highly dependent on the results of investigations. Registry data show that changes in cardiac index, mean right atrial pressure, and mean pulmonary artery pressure have the greatest influence on survival. It is recognized that pulmonary artery pressure (PASP) responses to PAH-specific drugs are heterogeneous. However, follow-up testing is strongly focused on assessing changes in PASP and functional status (6-min walk). The goals of therapy, which should be highlighted in follow-up imaging, include not only reduction of PASP, decrease in pulmonary vascular resistance, and improvements in right ventricular function, cardiac output, and tricuspid regurgitation. This paper reviews the echocardiographic follow-up of pulmonary hypertension, and especially focuses on right ventricular function—a major determinant of outcome, for which reliable echocardiographic assessment has become more feasible.
AB - Individual patient response to effective therapies for pulmonary hypertension (PAH) is variable and difficult to quantify. Consequently, management decisions regarding initiation and continuation of therapy are highly dependent on the results of investigations. Registry data show that changes in cardiac index, mean right atrial pressure, and mean pulmonary artery pressure have the greatest influence on survival. It is recognized that pulmonary artery pressure (PASP) responses to PAH-specific drugs are heterogeneous. However, follow-up testing is strongly focused on assessing changes in PASP and functional status (6-min walk). The goals of therapy, which should be highlighted in follow-up imaging, include not only reduction of PASP, decrease in pulmonary vascular resistance, and improvements in right ventricular function, cardiac output, and tricuspid regurgitation. This paper reviews the echocardiographic follow-up of pulmonary hypertension, and especially focuses on right ventricular function—a major determinant of outcome, for which reliable echocardiographic assessment has become more feasible.
KW - echocardiography
KW - follow-up
KW - magnetic resonance imaging
KW - pulmonary hypertension
KW - RV function
UR - http://www.scopus.com/inward/record.url?scp=84978217256&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2016.02.022
DO - 10.1016/j.jcmg.2016.02.022
M3 - Editorial
VL - 9
SP - 733
EP - 746
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
SN - 1876-7591
IS - 6
ER -