Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children

Jessica L. de Dassel; Halla Malik; Anna P. Ralph; Kate Hardie; Boglarka Remenyi; Joshua R. Francis

doi:10.4269/ajtmh.18-0907

Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children

Jessica L. de Dassel, Halla Malik, Anna P. Ralph, Kate Hardie, Boglarka Remenyi, Joshua R. Francis

Research output: Contribution to journal › Article

Abstract

This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87%). Eight recurrences (5%) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.

Original language	English
Pages (from-to)	1118-1120
Number of pages	3
Journal	The American Journal of Tropical Medicine and Hygiene
Volume	100
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.18-0907
Publication status	Published - 1 May 2019

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title = "Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children",

abstract = "This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87%). Eight recurrences (5%) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.",

author = "{de Dassel}, {Jessica L.} and Halla Malik and Ralph, {Anna P.} and Kate Hardie and Boglarka Remenyi and Francis, {Joshua R.}",

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Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children. / de Dassel, Jessica L.; Malik, Halla; Ralph, Anna P.; Hardie, Kate; Remenyi, Boglarka; Francis, Joshua R.

In: The American Journal of Tropical Medicine and Hygiene , Vol. 100, No. 5, 01.05.2019, p. 1118-1120.

Research output: Contribution to journal › Article

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AU - Remenyi, Boglarka

AU - Francis, Joshua R.

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