Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children

Jessica L. de Dassel, Halla Malik, Anna P. Ralph, Kate Hardie, Boglarka Remenyi, Joshua R. Francis

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87%). Eight recurrences (5%) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.

    Original languageEnglish
    Pages (from-to)1118-1120
    Number of pages3
    JournalThe American Journal of Tropical Medicine and Hygiene
    Volume100
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2019

    Fingerprint

    Penicillin G Benzathine
    Rheumatic Fever
    Recurrence
    Northern Territory

    Cite this

    de Dassel, Jessica L. ; Malik, Halla ; Ralph, Anna P. ; Hardie, Kate ; Remenyi, Boglarka ; Francis, Joshua R. / Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children. In: The American Journal of Tropical Medicine and Hygiene . 2019 ; Vol. 100, No. 5. pp. 1118-1120.
    @article{a95177ac31224b4085fe65a585da2b7c,
    title = "Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children",
    abstract = "This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87{\%}). Eight recurrences (5{\%}) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.",
    author = "{de Dassel}, {Jessica L.} and Halla Malik and Ralph, {Anna P.} and Kate Hardie and Boglarka Remenyi and Francis, {Joshua R.}",
    year = "2019",
    month = "5",
    day = "1",
    doi = "10.4269/ajtmh.18-0907",
    language = "English",
    volume = "100",
    pages = "1118--1120",
    journal = "The American Journal of Tropical Medicine and Hygiene",
    issn = "0002-9637",
    publisher = "American Society of Tropical Medicine and Hygiene",
    number = "5",

    }

    Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children. / de Dassel, Jessica L.; Malik, Halla; Ralph, Anna P.; Hardie, Kate; Remenyi, Boglarka; Francis, Joshua R.

    In: The American Journal of Tropical Medicine and Hygiene , Vol. 100, No. 5, 01.05.2019, p. 1118-1120.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Four-Weekly Benzathine Penicillin G Provides Inadequate Protection against Acute Rheumatic Fever in Some Children

    AU - de Dassel, Jessica L.

    AU - Malik, Halla

    AU - Ralph, Anna P.

    AU - Hardie, Kate

    AU - Remenyi, Boglarka

    AU - Francis, Joshua R.

    PY - 2019/5/1

    Y1 - 2019/5/1

    N2 - This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87%). Eight recurrences (5%) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.

    AB - This study aimed to identify recurrent acute rheumatic fever (ARF) episodes which occurred despite adherence to prophylactic benzathine penicillin G (BPG). Data from Australia's Northern Territory were analyzed; ARF recurrences between 2012 and 2017 diagnosed while the person was prescribed BPG were identified. Days at risk (DAR)-median and interquartile range-preceding ARF onset were calculated. The timing of BPG doses was examined for individuals with no DAR. One hundred sixty-nine ARF recurrences were analyzed; median DAR in the previous 8 weeks before ARF onset was 29. Most recurrences occurred following > 7 DAR (87%). Eight recurrences (5%) occurred despite no DAR; all were aged less than 16 years at the time of their recurrence/s. Recurrent ARF most commonly occurs after delayed BPG doses, but in some cases, receiving every prescribed BPG dose on time did not prevent recurrent ARF. A method to identify high-risk individuals before recurrent ARF is needed.

    UR - http://www.scopus.com/inward/record.url?scp=85065511641&partnerID=8YFLogxK

    U2 - 10.4269/ajtmh.18-0907

    DO - 10.4269/ajtmh.18-0907

    M3 - Article

    VL - 100

    SP - 1118

    EP - 1120

    JO - The American Journal of Tropical Medicine and Hygiene

    JF - The American Journal of Tropical Medicine and Hygiene

    SN - 0002-9637

    IS - 5

    ER -