Four year immunogenicity of the RTS,S/AS02 A malaria vaccine in Mozambican children during a phase IIb trial

Pedro Aide, Carlota Dobaño, Jahit Sacarlal, John Aponte, Inácio Mandomando, Caterina Guinovart, Quique Bassat, Montse Renom, Laura Puyol, Eusebio Macete, Esperanza Herreros, Amanda Leach, Marie-Claude Dubois, Marie Ange Demoitie, Marc Lievens, Johan Vekemans, Christian Loucq, Ripley Ballou, Joe Cohen, Pedro Alonso

    Research output: Contribution to journalArticle

    Abstract

    Previous studies with the malaria vaccine RTS,S/AS02A in young children in a malaria endemic area of Mozambique have shown it to have a promising safety profile and to reduce the risk of Plasmodium falciparum infection and disease. In this study, we assessed the antibody responses to the P. falciparum and hepatitis B components of the RTS,S/AS02A vaccine over a 45 months surveillance period in a large phase IIb trial which included 2022 children aged 1–4 years at recruitment. The RTS,S/AS02A vaccine induced high anti-circumsporozoite antibody levels with at least 96% of children remaining seropositive during the entire follow-up period. IgG titers decayed over the first 6 months of follow-up to about 25% of the initial level, but still remained 30-fold higher until month 45 compared to controls. Children with higher levels of naturally acquired immunity at baseline, assessed by blood stage indirect fluorescent antibody test, had slightly higher anti-circumsporozoite levels, after adjusting for the effect of age. The RTS,S/AS02A vaccine also induced high levels of anti-hepatitis B surface antigen antibodies (seroprotection >97%). RTS,S/AS02A vaccine is immunogenic and induces long-lasting anti-circumsporozoite antibodies, persisting at least 42 months after immunization. These antibodies may play a role in protection against malaria.
    Original languageEnglish
    Pages (from-to)6059-6067
    Number of pages9
    JournalVaccine
    Volume29
    Issue number35
    DOIs
    Publication statusPublished - 2011

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    Aide, P., Dobaño, C., Sacarlal, J., Aponte, J., Mandomando, I., Guinovart, C., ... Alonso, P. (2011). Four year immunogenicity of the RTS,S/AS02 A malaria vaccine in Mozambican children during a phase IIb trial. Vaccine, 29(35), 6059-6067. https://doi.org/10.1016/j.vaccine.2011.03.041