Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice

Rebekah E. Mcwhirter, James R. Marthick, Jacqueline A. Boyle, Joanne L. Dickinson

    Research output: Contribution to journalArticle

    Abstract

    Vulvar cancer is a relatively rare gynaecological malignancy, the treatment of which is associated with significant patient morbidity. With reports that the incidence of vulvar cancer is increasing, there is a rising need for improved preventive, diagnostic and therapeutic tools. Recent advances within genetics and epigenetics present possible approaches for addressing this need, by contributing to the clarification of the aetiology of this disease, identifying screening and drug targets and introducing the potential for personalised treatments. This paper reviews the genetic and epigenetic research undertaken to date within vulvar cancer, evaluates its potential for clinical application and identifies directions for future research. 

    Original languageEnglish
    Pages (from-to)406-411
    Number of pages6
    JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
    Volume54
    Issue number5
    DOIs
    Publication statusPublished - 2014

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