Genetic Diversity of Burkholderia pseudomallei Isolates in Australia

Allen Cheng, Linda Ward, Daniel Godoy, Robert Norton, Mark Mayo, D Gal, Brian Spratt, Bart Currie

    Research output: Contribution to journalArticle

    Abstract

    Melioidosis is caused by the gram-negative saprophytic bacterium Burkholderia pseudomallei, which is endemic to southeast Asia and northern Australia. We have previously found evidence of geographic localization of strains based on multilocus sequence typing (MLST). In this study, we examined the diversity of 277 isolates from northern Australia, which were resolved into 159 different sequence types. No sequence types were common to both Queensland and the Northern Territory, and there was significant differentiation between the alleles present in the two regions. The considerable diversity in sequence types contrasts with the limited diversity of alleles at MLST loci, supporting previous work suggesting a high rate of recombination relative to mutation in B. pseudomallei, where new sequence types are primarily generated by reassortment of existing alleles. Copyright � 2008, American Society for Microbiology. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)249-254
    Number of pages6
    JournalJournal of Clinical Microbiology
    Volume46
    Issue number1
    Publication statusPublished - 2008

    Fingerprint Dive into the research topics of 'Genetic Diversity of Burkholderia pseudomallei Isolates in Australia'. Together they form a unique fingerprint.

  • Cite this