Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Heidi Smith-Vaughan, Jemima Beissbarth, Jacinta Bowman, Kim Hare, Erin PRICE, Janessa Pickering, Deborah Lehmann, Anne Chang, Peter Morris, Robyn Marsh, Amanda Leach

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    Abstract

    Non-typeable Haemophilus influenzae (NTHi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world.NTHi strains retrieved from the upper airways commonly reflect
    those found in the lower airways. Despite growing genomic and genotyping data on NTHi, there remains a limited understanding of global and regional NTHi population structures. The aim of this study was to determine whether
    nasopharyngeal carriage in four Australian paediatric groups at varying risk of NTHi colonisation was dominated by the same NTHi genotypes. Genotyping data generated by PCR-ribotyping were evaluated for 3070 NTHi isolates colonising
    the nasopharynges of Aboriginal and non-Aboriginal children enrolled in four longitudinal studies in three separate urban and remote regions of Australia. Several NTHi PCR-ribotypes dominated in nasopharyngeal carriage, irrespective
    of study setting. Principal coordinates analysis confirmed a cluster of common PCR-ribotypes among all cohorts. In conclusion, we identified dominant PCR-ribotypes common to geographically disparate Australian paediatric
    populations. Future genomic analyses will shed further light on the precise factors underlying the dominance of certain NTHi strains in nasopharyngeal carriage.
    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalPneumonia
    Volume8
    Issue number13
    DOIs
    Publication statusPublished - 2016

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