TY - JOUR
T1 - Global impact of the COVID-19 pandemic on subarachnoid haemorrhage hospitalisations, aneurysm treatment and in-hospital mortality
T2 - 1-year follow-up
AU - SVIN Global COVID-19 SAH Registry
AU - Nguyen, Thanh N.
AU - Qureshi, Muhammad M.
AU - Klein, Piers
AU - Yamagami, Hiroshi
AU - Mikulik, Robert
AU - Etminan, Nima
AU - Abdalkader, Mohamad
AU - Mansour, Ossama Yassin
AU - Czlonkowska, Anna
AU - Lo, Hannah
AU - Sathya, Anvitha
AU - Demeestere, Jelle
AU - Tsivgoulis, Georgios
AU - Sakai, Nobuyuki
AU - Sedova, Petra
AU - Kristoffersen, Espen Saxhaug
AU - Mohammaden, Mahmoud
AU - Lereis, Virginia Pujol
AU - Scollo, Sergio Daniel
AU - Ma, Alice
AU - Rahman, Aminur
AU - Bonnet, Thomas
AU - Cortier, Jeroen
AU - Raedt, Sylvie De
AU - Lemmens, Robin
AU - Ligot, Noemie
AU - Hidalgo, Raquel C.T.
AU - Cuervo, Daissy Liliana Mora
AU - De Oliveira Neves, Luciana
AU - Rezende, Marco Tulio Salles
AU - Santiago, Igor Bessa
AU - Sirakov, Alexander
AU - Sirakov, Stanimir
AU - Cora, Elena Adela
AU - Kelly, Michael E.
AU - Lavoie, Pascale
AU - Peeling, Lissa
AU - Pikula, Aleksandra
AU - Rivera, Rodrigo
AU - Chen, Hui Sheng
AU - Chen, Yimin
AU - Fang, Hongliang
AU - Bedekovic, Marina Roje
AU - Budincevic, Hrvoje
AU - Strossmayer, J. J.
AU - Čabal, Martin
AU - Hrabanovska, Emanuela
AU - Jurak, Lubomir
AU - Kadlckova, Jana
AU - Karpowicz, Igor
AU - Klečka, Lukaš
AU - Kovař, Martin
AU - Neumann, Jiři
AU - Palouškova, Hana
AU - Reiser, Martin
AU - Rekova, Petra
AU - Škorňa, Miroslav
AU - Šramek, Martin
AU - Vitkova, Eva
AU - Žakova, Lenka
AU - Sobh, Khalid
AU - Alpay, Kemal
AU - Rautio, Riitta
AU - Strbian, Daniel
AU - Gentric, Jean Christophe
AU - Magro, Elsa
AU - Naggara, Olivier
AU - Reiner, Peggy
AU - Abdulazim, Amr
AU - Bohmann, Ferdinand O.
AU - Boskamp, Stefan
AU - Gerber, Johannes C.
AU - Kaiser, Daniel P.O.
AU - Kestner, Roxane Isabelle
AU - Mbroh, Joshua
AU - Neyazi, Milad
AU - Rosenkranz, Michael
AU - Poli, Sven
AU - Thomalla, Gotz
AU - Karapanayiotides, Theodoros
AU - Kargiotis, Odysseas
AU - Koutroulou, Ioanna
AU - Palaiodimou, Lina
AU - Guerra, Jose Domingo Barrientos
AU - Huded, Vikram
AU - Nagendra, Shashank
AU - Prajapati, Chintan
AU - Krishna, Angga
AU - Sani, Achmad Firdaus
AU - Ghoreishi, Abdoreza
AU - Ilkhchi, Reza Bahrami
AU - Jalili, Javad
AU - Sabetay, Sergiu Ionut
AU - Raya, Tariq Abu
AU - Acampa, Maurizio
AU - Longoni, Marco
AU - Bigliani, Claudia Rolla
AU - Castellan, Lucio
AU - Ornello, Raffaele
AU - Renieri, Leonardo
AU - Romoli, Michele
AU - Sacco, Simona
AU - Sangalli, Davide
AU - Vigano, Martina
AU - Zini, Andrea
AU - Tokimura, Hiroshi
AU - Sonoda, Kazutaka
AU - Todo, Kenichi
AU - Fukuda, Hiroki
AU - Fujita, Kyohei
AU - Sakaguchi, Manabu
AU - Uno, Masaaki
AU - Kan, Issei
AU - Kosuke, Miyake
AU - Kono, Ryuhei
AU - Kimura, Naoto
AU - Yamamoto, Nobuaki
AU - Yamamoto, Ryoo
AU - Doijiri, Ryosuke
AU - Shindo, Seigo
AU - Ohara, Nobuyuki
AU - Imamura, Hirotoshi
AU - Ogawa, Takehiro
AU - Uwatoko, Takeshi
AU - Kanamaru, Takuya
AU - Fujinaka, Toshiyuki
AU - Takenobu, Yohei
AU - Toyoda, Kazunori
AU - Matsumaru, Yuji
AU - Yazawa, Yukako
AU - Sugiura, Yuri
AU - Baek, Jang Hyun
AU - Kwon, Young Sub
AU - Lee, Yun Ho
AU - Seo, Kwon Duk
AU - Sohn, Sung Il
AU - Chan, Yong Chieh
AU - Wan Zaidi, Wan Asyraf
AU - Barrientos-Prieto, Javier
AU - Gongora-Rivera, Fernando
AU - Martinez-Marino, Manuel
AU - Calderon-Vallejo, Alejandra
AU - Groppa, Stanislav
AU - Pavel, Leahu
AU - Coutinho, Jonathan M.
AU - Dippel, Diederik
AU - Rinkel, Leon
AU - Van Dam-Nolen, Dianne H.K.
AU - Nwazor, Ernest Okwundu
AU - Sunmonu, Taofiki Ajao
AU - Al Hashmi, Amal M.
AU - Ahmad, Saima
AU - Rashid, Umair
AU - Rodriguez-Kadota, Liliana
AU - Vences, Miguel Angel
AU - Yalung, Patrick Matic
AU - Dy, Jon Stewart Hao
AU - Brola, Waldemar
AU - Dȩbiec, Aleksander
AU - Dorobek, Malgorzata
AU - Karlinski, Michal Adam
AU - Labuz-Roszak, Beata M.
AU - Lasek-Bal, Anetta
AU - Sienkiewicz-Jarosz, Halina
AU - Staszewski, Jacek
AU - Sobolewski, Piotr
AU - Wiącek, Marcin
AU - Zielinska-Turek, Justyna
AU - Araujo, Andre Pinho
AU - Fonseca, Luisa
AU - Silva, M. Luis
AU - Castro, Pedro
AU - Rocha, Mariana
AU - Falup-Pecurariu, Romania Cristian
AU - Venketasubramanian, Narayanaswamy
AU - Krastev, Georgi
AU - Mako, Miroslav
AU - Ayo-Martin, Oscar
AU - Blasco, Jordi
AU - Cruz-Culebras, Antonio
AU - Hernandez-Fernandez, Francisco
AU - Fernandez, Claudio Rodriguez
AU - Lopez, Jorge Escartin
AU - Rodriguez, Alejandro
AU - Bolognese, Manuel
AU - Karwacki, Grzegorz Marek
AU - Keller, Emanuela
AU - MacHi, Paolo
AU - Bernava, Gianmarco
AU - Boonyakarnkul, Surawan
AU - Churojana, Anchalee
AU - Hammami, Nadia
AU - Bajrami, Arsida
AU - Senadim, Songul
AU - Hussain, Syed I.
AU - John, Seby
AU - Dow, Graham
AU - Krishnan, Kailash
AU - Lenthall, Robert
AU - Wong, Ken
AU - Zhang, Liqun
AU - Altschul, Dorothea
AU - Asif, Kaiz S.
AU - Aziz-Sultan, Mohammad A.
AU - Bach, Ivo
AU - Bahiru, Zeelalem
AU - Below, Kristine
AU - Biller, Jose
AU - Cervantes-Arslanian, Anna M.
AU - Chaudhry, Saqib A.
AU - Chebl, Alex
AU - Chen, Michael
AU - Colasurdo, Marco
AU - Czap, Alexandra
AU - Dasenbrock, Hormuzdiyar
AU - De Havenon, Adam H.
AU - Dharmadhikari, Sushrut
AU - Dmytriw, Adam A.
AU - Eskey, Clifford J.
AU - Etherton, Mark
AU - Ezepue, Chizoba
AU - Fink, Lauren
AU - Gasimova, Ulviyya
AU - Goyal, Nitin
AU - Grimmett, Kasey B.
AU - Hakemi, Maryam
AU - Hester, Taryn
AU - Inoa, Violiza
AU - Kan, Peter T.
AU - Kasper, Ekkehard M.
AU - Khandelwal, Priyank
AU - Khatri, Rakesh
AU - Khawaja, Ayaz M.
AU - Khoury, Naim N.
AU - Kim, Benny S.
AU - Kolikonda, Murali
AU - Kuhn, Anna Luisa
AU - Linares, Guillermo
AU - Linfante, Italo
AU - Loochtan, Aaron I.
AU - Lukovits, Timothy G.
AU - Male, Shailesh S.
AU - Maali, Laith
AU - Masoud, Hesham E.
AU - Galecio-Castillo, Elsi Milagros
AU - Min, Jiangyong
AU - Mohamed, Ghada A.
AU - Nalleballe, Krishna
AU - Ortega-Gutierrez, Santiago
AU - Phan, Hoang Thi
N1 - Funding Information:
These coauthors have the following funding: support by STROCZECH within CZECRIN Large Research Infrastructure (number LM2018128) funded by the state budget of the Czech Republic. FNUSA: PS, RM, NCB and JR; lFN Hradec Králové: RH; FESO, FEANNemocnice Jihlava: OS; Hornická Nemocnice, a.s.: HP; Nemocnice Liberec: LJ; Nemocnice Na Homolce: MK; Vojenská Nemocnice Praha: MS, FP reported royalties from Springer Nature Publishing Group and Elsevier, Research Grant from Transilvania University Brasov, speaker fees and honoraria from International Parkinson and Movement Disorders Society, AbbVie, outside the submitted work. RM was supported by project number CA18118, IRENE COST Action funded by COST Association, by the IRIS-TEPUS project number LTC20051 from the INTER-EXCELLENCE INTER-COST Program of the Ministry of Education, Youth and Sports of the Czech Republic and by STROCZECH within CZECRIN Large Research Infrastructure number LM2018128 funded by the state budget of the Czech Republic. TNN reports research support from Medtronic and the Society of Vascular and Interventional Neurology. RGN reported consulting fees for advisory roles with Anaconda, Biogen, Cerenovus, Genentech, Hybernia, Imperative Care, Medtronic, Phenox, Philips, Prolong Pharmaceuticals, Stryker Neurovascular, Shanghai Wallaby and Synchron and stock options for advisory roles with Astrocyte, Brainomix, Cerebrotech, Ceretrieve, Corindus Vascular Robotics, Vesalio, Viz-AI, RapidPulse and Perfuze; and investments in Viz-AI, Perfuze, Cerebrotech, Reist/Q’Apel Medical, Truvic and Viseon. AP is a consultant for Cerenovus, CereVasc, Merit and Medtronic; received research grants from Medtronic. Stocks in InNeuroCo, Galaxy, Agile, Perfuze and NTI. HY reported research grants from Bristol-Myers Squibb, lecturer’s fees from Bayer, Daiichi-Sankyo and Stryker, and membership in the advisory boards for Daiichi-Sankyo outside the submitted work. Dr. Siegler reports speakers bureau from AstraZeneca, consulting fees from Ceribell.
Funding Information:
The study was funded by the Society of Vascular and Interventional Neurology research pilot grant.
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background Prior studies indicated a decrease in the incidences of aneurysmal subarachnoid haemorrhage (aSAH) during the early stages of the COVID-19 pandemic. We evaluated differences in the incidence, severity of aSAH presentation, and ruptured aneurysm treatment modality during the first year of the COVID-19 pandemic compared with the preceding year. Methods We conducted a cross-sectional study including 49 countries and 187 centres. We recorded volumes for COVID-19 hospitalisations, aSAH hospitalisations, Hunt-Hess grade, coiling, clipping and aSAH in-hospital mortality. Diagnoses were identified by International Classification of Diseases, 10th Revision, codes or stroke databases from January 2019 to May 2021. Results Over the study period, there were 16 247 aSAH admissions, 344 491 COVID-19 admissions, 8300 ruptured aneurysm coiling and 4240 ruptured aneurysm clipping procedures. Declines were observed in aSAH admissions (-6.4% (95% CI-7.0% to-5.8%), p=0.0001) during the first year of the pandemic compared with the prior year, most pronounced in high-volume SAH and high-volume COVID-19 hospitals. There was a trend towards a decline in mild and moderate presentations of subarachnoid haemorrhage (SAH) (mild:-5% (95% CI-5.9% to-4.3%), p=0.06; moderate:-8.3% (95% CI-10.2% to-6.7%), p=0.06) but no difference in higher SAH severity. The ruptured aneurysm clipping rate remained unchanged (30.7% vs 31.2%, p=0.58), whereas ruptured aneurysm coiling increased (53.97% vs 56.5%, p=0.009). There was no difference in aSAH in-hospital mortality rate (19.1% vs 20.1%, p=0.12). Conclusion During the first year of the pandemic, there was a decrease in aSAH admissions volume, driven by a decrease in mild to moderate presentation of aSAH. There was an increase in the ruptured aneurysm coiling rate but neither change in the ruptured aneurysm clipping rate nor change in aSAH in-hospital mortality. Trial registration number NCT04934020.
AB - Background Prior studies indicated a decrease in the incidences of aneurysmal subarachnoid haemorrhage (aSAH) during the early stages of the COVID-19 pandemic. We evaluated differences in the incidence, severity of aSAH presentation, and ruptured aneurysm treatment modality during the first year of the COVID-19 pandemic compared with the preceding year. Methods We conducted a cross-sectional study including 49 countries and 187 centres. We recorded volumes for COVID-19 hospitalisations, aSAH hospitalisations, Hunt-Hess grade, coiling, clipping and aSAH in-hospital mortality. Diagnoses were identified by International Classification of Diseases, 10th Revision, codes or stroke databases from January 2019 to May 2021. Results Over the study period, there were 16 247 aSAH admissions, 344 491 COVID-19 admissions, 8300 ruptured aneurysm coiling and 4240 ruptured aneurysm clipping procedures. Declines were observed in aSAH admissions (-6.4% (95% CI-7.0% to-5.8%), p=0.0001) during the first year of the pandemic compared with the prior year, most pronounced in high-volume SAH and high-volume COVID-19 hospitals. There was a trend towards a decline in mild and moderate presentations of subarachnoid haemorrhage (SAH) (mild:-5% (95% CI-5.9% to-4.3%), p=0.06; moderate:-8.3% (95% CI-10.2% to-6.7%), p=0.06) but no difference in higher SAH severity. The ruptured aneurysm clipping rate remained unchanged (30.7% vs 31.2%, p=0.58), whereas ruptured aneurysm coiling increased (53.97% vs 56.5%, p=0.009). There was no difference in aSAH in-hospital mortality rate (19.1% vs 20.1%, p=0.12). Conclusion During the first year of the pandemic, there was a decrease in aSAH admissions volume, driven by a decrease in mild to moderate presentation of aSAH. There was an increase in the ruptured aneurysm coiling rate but neither change in the ruptured aneurysm clipping rate nor change in aSAH in-hospital mortality. Trial registration number NCT04934020.
KW - CEREBROVASCULAR DISEASE
KW - COVID-19
KW - SUBARACHNOID HAEMORRHAGE
UR - https://www.scopus.com/pages/publications/85134306667
U2 - 10.1136/jnnp-2022-329200
DO - 10.1136/jnnp-2022-329200
M3 - Article
C2 - 35902229
AN - SCOPUS:85134306667
SN - 0022-3050
VL - 93
SP - 1028
EP - 1038
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 10
ER -
SDG 3 Good Health and Well-being