Greater Endothelial Activation, Weibel-Palade body Release and Host Inflammatory Response to Plasmodium vivax, Compared with Plasmodium falciparum: A Prospective Study in Papua,Indonesia

Tsin Yeo, Daniel Lampah, Emiliana Tjitra, Kim Piera, Retno Gitawati, Enny Kenangalem, Ric Price, Nicholas Anstey

Research output: Contribution to journalArticlepeer-review

Abstract

Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum. � 2010 by the Infectious Diseases Society of America. All rights reserved.
Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalJournal of Infectious Diseases
Volume202
Issue number1
DOIs
Publication statusPublished - 1 Jul 2010

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