@article{b6048cd1edd640d2bb6a032335447943,
title = "Greater Endothelial Activation, Weibel-Palade body Release and Host Inflammatory Response to Plasmodium vivax, Compared with Plasmodium falciparum: A Prospective Study in Papua,Indonesia",
abstract = "Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum. � 2010 by the Infectious Diseases Society of America. All rights reserved.",
keywords = "angiopoietin 2, antimalarial agent, cytokine, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule 1, interleukin 10, interleukin 6, SELE protein, human, adult, article, cell activation, clinical trial, female, human, Indonesia, inflammation, major clinical study, malaria, malaria falciparum, male, Plasmodium falciparum, Plasmodium vivax, Plasmodium vivax malaria, priority journal, Weibel Palade body, animal, gene expression regulation, genetics, immunology, metabolism, Animals, E-Selectin, Gene Expression Regulation, Humans, Inflammation, Intercellular Adhesion Molecule-1, Interleukin-10, Interleukin-6, Malaria, Falciparum, Malaria, Vivax, Weibel-Palade Bodies",
author = "Tsin Yeo and Daniel Lampah and Emiliana Tjitra and Kim Piera and Retno Gitawati and Enny Kenangalem and Ric Price and Nicholas Anstey",
year = "2010",
month = jul,
day = "1",
doi = "10.1086/653211",
language = "English",
volume = "202",
pages = "109--112",
journal = "The Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}