Healthy Body Weight may Modify Effect of Abnormal Birth Weight on Metabolic Syndrome in Adolescents

Bin Dong, Yan-Hui Dong, Zhao-Geng Yang, Xi-Jie Wang, Zhi-Yong Zou, Zhiqiang Wang, Jun Ma (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to examine the association between birth weight (BW) and metabolic syndrome (MetS) in adolescents and to further investigate whether having a healthy body weight could modify the potential adverse influence of abnormal BW on MetS risk.

Methods: A total of 6,206 participants aged 10 to 17 years were recruited using data from a Chinese national survey conducted in 2012. Gestational age‐specific BW percentiles were used to classify small for gestational age (SGA), appropriate for gestational age, and large for gestational age (LGA). Fractional polynomial regression, logistic regression, and population‐attributable risk (PAR) were used to assess the relationship between BMI and BW with MetS.

Results: MetS risk increased by 73% (OR = 1.73, 95% CI: 1.06‐2.84) in SGA adolescents with overweight or obesity, but not in those without overweight, compared with their counterparts with BW appropriate for gestational age. A huge difference between PAR percent of MetS because of SGA and PAR percent because of overweight or obesity was detected. For example, PAR percent of SGA was 2.4% (95% CI: 0.1%‐4.6%) in adolescents with overweight or obesity, while PAR percent of overweight or obesity was 44.2% (95% CI: 33.3%‐53.2%) in those who were SGA infants.

Conclusions: These findings suggest that healthy body weight could relieve the adverse impact of SGA on MetS in adolescents.
Original languageEnglish
Pages (from-to)462-469
Number of pages8
JournalObesity
Volume27
Issue number3
DOIs
Publication statusPublished - 2019
Externally publishedYes

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    Dong, B., Dong, Y-H., Yang, Z-G., Wang, X-J., Zou, Z-Y., Wang, Z., & Ma, J. (2019). Healthy Body Weight may Modify Effect of Abnormal Birth Weight on Metabolic Syndrome in Adolescents. Obesity, 27(3), 462-469. https://doi.org/10.1002/oby.22391