Heroes or villains? T regulatory cells in malaria infection

A SCHOLZEN, Gabriela Minigo, M PLEBANSKI

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalTrends in Parasitology
Volume26
Issue number1
Publication statusPublished - 2009

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Regulatory T-Lymphocytes
Malaria
Parasites
Infection
Parasitemia
Homeostasis
Inflammation

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SCHOLZEN, A ; Minigo, Gabriela ; PLEBANSKI, M. / Heroes or villains? T regulatory cells in malaria infection. In: Trends in Parasitology. 2009 ; Vol. 26, No. 1. pp. 16-25.
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SCHOLZEN, A, Minigo, G & PLEBANSKI, M 2009, 'Heroes or villains? T regulatory cells in malaria infection', Trends in Parasitology, vol. 26, no. 1, pp. 16-25.

Heroes or villains? T regulatory cells in malaria infection. / SCHOLZEN, A; Minigo, Gabriela; PLEBANSKI, M.

In: Trends in Parasitology, Vol. 26, No. 1, 2009, p. 16-25.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Heroes or villains? T regulatory cells in malaria infection

AU - SCHOLZEN, A

AU - Minigo, Gabriela

AU - PLEBANSKI, M

PY - 2009

Y1 - 2009

N2 - Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.

AB - Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.

KW - interleukin 10

KW - interleukin 2 receptor alpha

KW - interleukin 7 receptor

KW - toll like receptor 9

KW - transcription factor FOXP3

KW - transforming growth factor beta

KW - tumor necrosis factor receptor 2

KW - adaptive immunity

KW - antigen presenting cell

KW - C57BL 6 mouse

KW - CD4+ CD25+ T lymphocyte

KW - effector cell

KW - human

KW - immune response

KW - immunopathology

KW - immunoregulation

KW - inflammation

KW - malaria

KW - nonhuman

KW - parasitemia

KW - Plasmodium falciparum

KW - protein expression

KW - regulatory T lymphocyte

KW - review

KW - T lymphocyte activation

KW - Th1 cell

KW - Animals

KW - Humans

KW - Malaria, Falciparum

KW - Mice

KW - T-Lymphocytes, Regulatory

KW - Murinae

KW - Plasmodium parasites

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JO - Trends in Parasitology

JF - Trends in Parasitology

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