Heroes or villains? T regulatory cells in malaria infection

A SCHOLZEN, Gabriela Minigo, M PLEBANSKI

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)16-25
    Number of pages10
    JournalTrends in Parasitology
    Volume26
    Issue number1
    Publication statusPublished - 2009

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    Regulatory T-Lymphocytes
    Malaria
    Parasites
    Infection
    Parasitemia
    Homeostasis
    Inflammation

    Cite this

    SCHOLZEN, A ; Minigo, Gabriela ; PLEBANSKI, M. / Heroes or villains? T regulatory cells in malaria infection. In: Trends in Parasitology. 2009 ; Vol. 26, No. 1. pp. 16-25.
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    abstract = "Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.",
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    SCHOLZEN, A, Minigo, G & PLEBANSKI, M 2009, 'Heroes or villains? T regulatory cells in malaria infection', Trends in Parasitology, vol. 26, no. 1, pp. 16-25.

    Heroes or villains? T regulatory cells in malaria infection. / SCHOLZEN, A; Minigo, Gabriela; PLEBANSKI, M.

    In: Trends in Parasitology, Vol. 26, No. 1, 2009, p. 16-25.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Heroes or villains? T regulatory cells in malaria infection

    AU - SCHOLZEN, A

    AU - Minigo, Gabriela

    AU - PLEBANSKI, M

    PY - 2009

    Y1 - 2009

    N2 - Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.

    AB - Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.

    KW - interleukin 10

    KW - interleukin 2 receptor alpha

    KW - interleukin 7 receptor

    KW - toll like receptor 9

    KW - transcription factor FOXP3

    KW - transforming growth factor beta

    KW - tumor necrosis factor receptor 2

    KW - adaptive immunity

    KW - antigen presenting cell

    KW - C57BL 6 mouse

    KW - CD4+ CD25+ T lymphocyte

    KW - effector cell

    KW - human

    KW - immune response

    KW - immunopathology

    KW - immunoregulation

    KW - inflammation

    KW - malaria

    KW - nonhuman

    KW - parasitemia

    KW - Plasmodium falciparum

    KW - protein expression

    KW - regulatory T lymphocyte

    KW - review

    KW - T lymphocyte activation

    KW - Th1 cell

    KW - Animals

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    KW - Malaria, Falciparum

    KW - Mice

    KW - T-Lymphocytes, Regulatory

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    KW - Plasmodium parasites

    M3 - Article

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