Heroes or villains? T regulatory cells in malaria infection

A SCHOLZEN, Gabriela Minigo, M PLEBANSKI

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection. � 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalTrends in Parasitology
Volume26
Issue number1
Publication statusPublished - 2009

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