Abstract
Original language | English |
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Pages (from-to) | 445-450 |
Number of pages | 6 |
Journal | Journal of Infectious Diseases |
Volume | 199 |
Issue number | 3 |
Publication status | Published - 2009 |
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High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. / HANDAYANI, S; CHIU, D; TJITRA, E; KUO, J; LAMPAH, D; Kenangalem, Enny; RENIA, L; SNOUNOU, G; Price, Ric; Anstey, Nicholas; Russell, Bruce.
In: Journal of Infectious Diseases, Vol. 199, No. 3, 2009, p. 445-450.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions
AU - HANDAYANI, S
AU - CHIU, D
AU - TJITRA, E
AU - KUO, J
AU - LAMPAH, D
AU - Kenangalem, Enny
AU - RENIA, L
AU - SNOUNOU, G
AU - Price, Ric
AU - Anstey, Nicholas
AU - Russell, Bruce
PY - 2009
Y1 - 2009
N2 - Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-?m microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-?m constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria. � 2008 by the Infectious Diseases Society of America. All rights reserved.
AB - Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-?m microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-?m constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria. � 2008 by the Infectious Diseases Society of America. All rights reserved.
KW - anemia
KW - article
KW - controlled study
KW - erythrocyte
KW - microfluidics
KW - nonhuman
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - Plasmodium vivax malaria
KW - priority journal
KW - schizont
KW - spleen
KW - trophozoite
KW - Animals
KW - Erythrocyte Deformability
KW - Erythrocytes
KW - Humans
KW - Malaria, Falciparum
KW - Malaria, Vivax
KW - Microfluidics
UR - http://www.scopus.com/inward/record.url?scp=58849145833&partnerID=8YFLogxK
M3 - Article
VL - 199
SP - 445
EP - 450
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -