High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions

S HANDAYANI, D CHIU, E TJITRA, J KUO, D LAMPAH, Enny Kenangalem, L RENIA, G SNOUNOU, Ric Price, Nicholas Anstey, Bruce Russell

Research output: Contribution to journalArticlepeer-review

Abstract

Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-?m microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-?m constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria. � 2008 by the Infectious Diseases Society of America. All rights reserved.
Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalJournal of Infectious Diseases
Volume199
Issue number3
Publication statusPublished - 2009

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