High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases

A Population-Based Study

N. Homaira, N. Briggs, J. Oei, L. Hilder, B. Bajuk, T. Snelling, A. Jaffe

    Research output: Contribution to journalMeeting AbstractResearch

    Abstract

    Introduction/Aim: Severe influenza infection in children with chronic lung diseases results in, unscheduled hospital presentations and substantial burden to the health system. National influenza burden data in children with chronic lung diseases are limited. Such data are crucial to monitor burden of disease and evaluate effectiveness of influenza vaccination program. We conducted a retrospective population‐based cohort study to measure the impact of influenza on hospitalisation rates in children with chronic lung diseases.

    Methods: We performed a retrospective cohort study using population‐based linked administrative data for all children born in New South Wales between 2001‐2010 with complete follow‐up until December 31st 2011. The cohort was divided in to two groups: i) children with chronic lung diseases including all children with asthma, bronchopulmonary dysplasia, cystic fibrosis, and congenital lung disorders; and ii) all other standard‐risk children.

    The primary outcome was any episode of influenza associated hospitalisation (ICD codes J.09‐J11). Incidence rates for influenza hospitalisation were calculated for 2001‐2011. We used Poisson estimation to calculate 95% confidence interval around incidences.

    Results: Our cohort comprised of 9,708 children with chronic lung diseases and 877,240 standard‐risk children. The adjusted rate/1000 child‐years of influenza hospitalisation in children with chronic lung diseases was 5.21 (95% CI 2.57‐7.84) and for all other standard‐risk children was 0.92 (95% CI 0.46‐1.38). During 2001‐2011, the rate in children with chronic lung diseases ranged between 0.20‐12.57/1000 child‐years. The rate/1000 child‐years was similar in male and female children with chronic lung diseases and was 5.45 (95% CI 2.63‐8.26) for boys and 5.15 (95% CI 2.41‐7.89) for girls.

    Conclusion:
    Our study has demonstrated that children with chronic diseases are at least five times more at risk of being hospitalised with influenza than standard‐risk children. Future studies investigating the effectiveness of universal vaccination program for these and all other children may help reduce the burden.
    Original languageEnglish
    Article numberTO-114
    Pages (from-to)82-82
    Number of pages1
    JournalRespirology
    Volume23
    Issue numberS1
    DOIs
    Publication statusPublished - 14 Mar 2018

    Fingerprint

    Human Influenza
    Lung Diseases
    Hospitalization
    Chronic Disease
    Population
    Vaccination
    Cohort Studies
    Bronchopulmonary Dysplasia
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    New South Wales
    Incidence
    International Classification of Diseases
    Cystic Fibrosis
    Asthma
    Retrospective Studies

    Cite this

    Homaira, N., Briggs, N., Oei, J., Hilder, L., Bajuk, B., Snelling, T., & Jaffe, A. (2018). High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases: A Population-Based Study. Respirology, 23(S1), 82-82. [TO-114]. https://doi.org/10.1111/resp.13267
    Homaira, N. ; Briggs, N. ; Oei, J. ; Hilder, L. ; Bajuk, B. ; Snelling, T. ; Jaffe, A. / High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases : A Population-Based Study. In: Respirology. 2018 ; Vol. 23, No. S1. pp. 82-82.
    @article{95e0ae86d04a431f8bc3b911fef937bd,
    title = "High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases: A Population-Based Study",
    abstract = "Introduction/Aim: Severe influenza infection in children with chronic lung diseases results in, unscheduled hospital presentations and substantial burden to the health system. National influenza burden data in children with chronic lung diseases are limited. Such data are crucial to monitor burden of disease and evaluate effectiveness of influenza vaccination program. We conducted a retrospective population‐based cohort study to measure the impact of influenza on hospitalisation rates in children with chronic lung diseases.Methods: We performed a retrospective cohort study using population‐based linked administrative data for all children born in New South Wales between 2001‐2010 with complete follow‐up until December 31st 2011. The cohort was divided in to two groups: i) children with chronic lung diseases including all children with asthma, bronchopulmonary dysplasia, cystic fibrosis, and congenital lung disorders; and ii) all other standard‐risk children.The primary outcome was any episode of influenza associated hospitalisation (ICD codes J.09‐J11). Incidence rates for influenza hospitalisation were calculated for 2001‐2011. We used Poisson estimation to calculate 95{\%} confidence interval around incidences.Results: Our cohort comprised of 9,708 children with chronic lung diseases and 877,240 standard‐risk children. The adjusted rate/1000 child‐years of influenza hospitalisation in children with chronic lung diseases was 5.21 (95{\%} CI 2.57‐7.84) and for all other standard‐risk children was 0.92 (95{\%} CI 0.46‐1.38). During 2001‐2011, the rate in children with chronic lung diseases ranged between 0.20‐12.57/1000 child‐years. The rate/1000 child‐years was similar in male and female children with chronic lung diseases and was 5.45 (95{\%} CI 2.63‐8.26) for boys and 5.15 (95{\%} CI 2.41‐7.89) for girls.Conclusion: Our study has demonstrated that children with chronic diseases are at least five times more at risk of being hospitalised with influenza than standard‐risk children. Future studies investigating the effectiveness of universal vaccination program for these and all other children may help reduce the burden.",
    keywords = "Respiratory System",
    author = "N. Homaira and N. Briggs and J. Oei and L. Hilder and B. Bajuk and T. Snelling and A. Jaffe",
    year = "2018",
    month = "3",
    day = "14",
    doi = "10.1111/resp.13267",
    language = "English",
    volume = "23",
    pages = "82--82",
    journal = "Respirology",
    issn = "1323-7799",
    publisher = "Wiley-Blackwell",
    number = "S1",

    }

    Homaira, N, Briggs, N, Oei, J, Hilder, L, Bajuk, B, Snelling, T & Jaffe, A 2018, 'High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases: A Population-Based Study', Respirology, vol. 23, no. S1, TO-114, pp. 82-82. https://doi.org/10.1111/resp.13267

    High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases : A Population-Based Study. / Homaira, N.; Briggs, N.; Oei, J.; Hilder, L.; Bajuk, B.; Snelling, T.; Jaffe, A.

    In: Respirology, Vol. 23, No. S1, TO-114, 14.03.2018, p. 82-82.

    Research output: Contribution to journalMeeting AbstractResearch

    TY - JOUR

    T1 - High Impact of Influenza on Hospitalisation Rates in Children with Chronic Lung Diseases

    T2 - A Population-Based Study

    AU - Homaira, N.

    AU - Briggs, N.

    AU - Oei, J.

    AU - Hilder, L.

    AU - Bajuk, B.

    AU - Snelling, T.

    AU - Jaffe, A.

    PY - 2018/3/14

    Y1 - 2018/3/14

    N2 - Introduction/Aim: Severe influenza infection in children with chronic lung diseases results in, unscheduled hospital presentations and substantial burden to the health system. National influenza burden data in children with chronic lung diseases are limited. Such data are crucial to monitor burden of disease and evaluate effectiveness of influenza vaccination program. We conducted a retrospective population‐based cohort study to measure the impact of influenza on hospitalisation rates in children with chronic lung diseases.Methods: We performed a retrospective cohort study using population‐based linked administrative data for all children born in New South Wales between 2001‐2010 with complete follow‐up until December 31st 2011. The cohort was divided in to two groups: i) children with chronic lung diseases including all children with asthma, bronchopulmonary dysplasia, cystic fibrosis, and congenital lung disorders; and ii) all other standard‐risk children.The primary outcome was any episode of influenza associated hospitalisation (ICD codes J.09‐J11). Incidence rates for influenza hospitalisation were calculated for 2001‐2011. We used Poisson estimation to calculate 95% confidence interval around incidences.Results: Our cohort comprised of 9,708 children with chronic lung diseases and 877,240 standard‐risk children. The adjusted rate/1000 child‐years of influenza hospitalisation in children with chronic lung diseases was 5.21 (95% CI 2.57‐7.84) and for all other standard‐risk children was 0.92 (95% CI 0.46‐1.38). During 2001‐2011, the rate in children with chronic lung diseases ranged between 0.20‐12.57/1000 child‐years. The rate/1000 child‐years was similar in male and female children with chronic lung diseases and was 5.45 (95% CI 2.63‐8.26) for boys and 5.15 (95% CI 2.41‐7.89) for girls.Conclusion: Our study has demonstrated that children with chronic diseases are at least five times more at risk of being hospitalised with influenza than standard‐risk children. Future studies investigating the effectiveness of universal vaccination program for these and all other children may help reduce the burden.

    AB - Introduction/Aim: Severe influenza infection in children with chronic lung diseases results in, unscheduled hospital presentations and substantial burden to the health system. National influenza burden data in children with chronic lung diseases are limited. Such data are crucial to monitor burden of disease and evaluate effectiveness of influenza vaccination program. We conducted a retrospective population‐based cohort study to measure the impact of influenza on hospitalisation rates in children with chronic lung diseases.Methods: We performed a retrospective cohort study using population‐based linked administrative data for all children born in New South Wales between 2001‐2010 with complete follow‐up until December 31st 2011. The cohort was divided in to two groups: i) children with chronic lung diseases including all children with asthma, bronchopulmonary dysplasia, cystic fibrosis, and congenital lung disorders; and ii) all other standard‐risk children.The primary outcome was any episode of influenza associated hospitalisation (ICD codes J.09‐J11). Incidence rates for influenza hospitalisation were calculated for 2001‐2011. We used Poisson estimation to calculate 95% confidence interval around incidences.Results: Our cohort comprised of 9,708 children with chronic lung diseases and 877,240 standard‐risk children. The adjusted rate/1000 child‐years of influenza hospitalisation in children with chronic lung diseases was 5.21 (95% CI 2.57‐7.84) and for all other standard‐risk children was 0.92 (95% CI 0.46‐1.38). During 2001‐2011, the rate in children with chronic lung diseases ranged between 0.20‐12.57/1000 child‐years. The rate/1000 child‐years was similar in male and female children with chronic lung diseases and was 5.45 (95% CI 2.63‐8.26) for boys and 5.15 (95% CI 2.41‐7.89) for girls.Conclusion: Our study has demonstrated that children with chronic diseases are at least five times more at risk of being hospitalised with influenza than standard‐risk children. Future studies investigating the effectiveness of universal vaccination program for these and all other children may help reduce the burden.

    KW - Respiratory System

    U2 - 10.1111/resp.13267

    DO - 10.1111/resp.13267

    M3 - Meeting Abstract

    VL - 23

    SP - 82

    EP - 82

    JO - Respirology

    JF - Respirology

    SN - 1323-7799

    IS - S1

    M1 - TO-114

    ER -