Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination

Results from the Ausimmune Study

Samuel Hoare, Fiona Lithander, Ingrid Van Der Mei, Anne-Louise Ponsonby, Robyn Lucas, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn M. Lucas, Tony McMichael, Michael P. Pender, Bruce Taylor, Patricia C. Valery, David Williams

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). 

Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). 

Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. 

Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. 

Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.

Original languageEnglish
Pages (from-to)884-892
Number of pages9
JournalMultiple Sclerosis
Volume22
Issue number7
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

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Omega-3 Fatty Acids
Demyelinating Diseases
Unsaturated Fatty Acids
Central Nervous System
Fats
Dietary Fats
Fishes
Multiple Sclerosis
Case-Control Studies
Odds Ratio
Food

Cite this

Hoare, Samuel ; Lithander, Fiona ; Van Der Mei, Ingrid ; Ponsonby, Anne-Louise ; Lucas, Robyn ; Chapman, Caron ; Coulthard, Alan ; Dear, Keith ; Dwyer, Terry ; Kilpatrick, Trevor ; Lucas, Robyn M. ; McMichael, Tony ; Pender, Michael P. ; Taylor, Bruce ; Valery, Patricia C. ; Williams, David. / Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination : Results from the Ausimmune Study. In: Multiple Sclerosis. 2016 ; Vol. 22, No. 7. pp. 884-892.
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title = "Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study",
abstract = "Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95{\%} CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95{\%} CI 0.31-0.93)) rather than from plants (AOR=0.75 (95{\%} CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.",
keywords = "diet, fat, first demyelinating event, monounsaturated fat, Multiple sclerosis, omega-3 fatty acids, polyunsaturated fat, saturated fat",
author = "Samuel Hoare and Fiona Lithander and {Van Der Mei}, Ingrid and Anne-Louise Ponsonby and Robyn Lucas and Caron Chapman and Alan Coulthard and Keith Dear and Terry Dwyer and Trevor Kilpatrick and Lucas, {Robyn M.} and Tony McMichael and Pender, {Michael P.} and Bruce Taylor and Valery, {Patricia C.} and David Williams",
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journal = "Multiple Sclerosis",
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Hoare, S, Lithander, F, Van Der Mei, I, Ponsonby, A-L, Lucas, R, Chapman, C, Coulthard, A, Dear, K, Dwyer, T, Kilpatrick, T, Lucas, RM, McMichael, T, Pender, MP, Taylor, B, Valery, PC & Williams, D 2016, 'Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study', Multiple Sclerosis, vol. 22, no. 7, pp. 884-892. https://doi.org/10.1177/1352458515604380

Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination : Results from the Ausimmune Study. / Hoare, Samuel; Lithander, Fiona; Van Der Mei, Ingrid; Ponsonby, Anne-Louise; Lucas, Robyn; Chapman, Caron; Coulthard, Alan; Dear, Keith; Dwyer, Terry; Kilpatrick, Trevor; Lucas, Robyn M.; McMichael, Tony; Pender, Michael P.; Taylor, Bruce; Valery, Patricia C.; Williams, David.

In: Multiple Sclerosis, Vol. 22, No. 7, 01.06.2016, p. 884-892.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination

T2 - Results from the Ausimmune Study

AU - Hoare, Samuel

AU - Lithander, Fiona

AU - Van Der Mei, Ingrid

AU - Ponsonby, Anne-Louise

AU - Lucas, Robyn

AU - Chapman, Caron

AU - Coulthard, Alan

AU - Dear, Keith

AU - Dwyer, Terry

AU - Kilpatrick, Trevor

AU - Lucas, Robyn M.

AU - McMichael, Tony

AU - Pender, Michael P.

AU - Taylor, Bruce

AU - Valery, Patricia C.

AU - Williams, David

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.

AB - Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.

KW - diet

KW - fat

KW - first demyelinating event

KW - monounsaturated fat

KW - Multiple sclerosis

KW - omega-3 fatty acids

KW - polyunsaturated fat

KW - saturated fat

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