Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study

Samuel Hoare, Fiona Lithander, Ingrid Van Der Mei, Anne-Louise Ponsonby, Robyn Lucas, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn M. Lucas, Tony McMichael, Michael P. Pender, Bruce Taylor, Patricia C. Valery, David Williams

Research output: Contribution to journalArticle

Abstract

Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). 

Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). 

Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. 

Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. 

Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.

Original languageEnglish
Pages (from-to)884-892
Number of pages9
JournalMultiple Sclerosis
Volume22
Issue number7
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

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Hoare, S., Lithander, F., Van Der Mei, I., Ponsonby, A-L., Lucas, R., Chapman, C., Coulthard, A., Dear, K., Dwyer, T., Kilpatrick, T., Lucas, R. M., McMichael, T., Pender, M. P., Taylor, B., Valery, P. C., & Williams, D. (2016). Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study. Multiple Sclerosis, 22(7), 884-892. https://doi.org/10.1177/1352458515604380