Highly Effective Therapy for Maternal Malaria Associated With a Lower Risk of Vertical Transmission

Jeanne Rini Poespoprodjo, W FOBIA, Enny Kenangalem, A HASANUDDIN, P SUGIARTO, Emiliana Tjitra, Nicholas Anstey, Ric Price

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Background: The epidemiology of congenital malaria was investigated in a hospital-based malaria surveillance study in Papua, Indonesia.

Methods: From April 2005 to January 2010, 4878 delivering women and their newborns underwent prospective clinical review and malaria screening by peripheral blood microscopy.

Findings: Congenital malaria occurred in 8 per 1000 (38/4884) live births, with Plasmodium falciparum accounting for 76.3% (29) and P. vivax for 15.8% (6) of infections. Maternal malaria at delivery (adjusted odds ratio [AOR], 9.5; 95% confidence interval [CI], 4.2-21.5; P <. 001), age ? 16 years (AOR, 4; 95% CI, 1.4-12.1; P =. 011), and prior malaria during pregnancy (AOR, 2.2; 95% CI, 1.1-4.4, P =. 022) were independent risk factors for vertical transmission. Of 29 mothers and neonates with contemporaneous peripheral parasitemia, 17% (5) had discordant parasite species, suggesting possible antenatal malaria transmission. Newborns with malaria were at significantly greater risk of low birth weight (AOR, 2.8; 95% CI, 1.2-6.6; P =. 002). Following introduction of dihydroartemisinin-piperaquine for uncomplicated malaria in the second and third trimesters of pregnancy, congenital malaria incidence fell from 3.2% to 0.2% (odds ratio, 0.07; 95% CI,. 03-.15; P <. 001).

Conclusions: Congenital malaria is an important cause of neonatal morbidity in this region co-endemic for P. falciparum and P. vivax malaria. The introduction of artemisinin-combination therapy was associated with a significant risk reduction in the vertical transmission of malaria. 

Original languageEnglish
Pages (from-to)1613-1619
Number of pages7
JournalJournal of Infectious Diseases
Issue number10
Publication statusPublished - 2011


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