Hot topics in necrotising skin and soft tissue infections

International Society of Antimicrobial Chemotherapy

    Research output: Contribution to journalEditorialResearchpeer-review

    Abstract

    Skin and soft tissue infections (SSTI) are amongst the most common infections encountered in clinical practice. Most infections do not result in skin or tissue necrosis; however, those that do are associated with a high mortality rate. In addition, because of the surreptitious presentation of the disease, clinical recognition is often delayed, resulting in rapid and overwhelming morbidity.

    Necrotising skin and soft tissue infections (NSSTI) are a spectrum of conditions and their presentation can vary depending on the host and microbial factors. NSSTI can spread in the superficial skin layers causing a necrotising cellulitis, or within deeper skin layers along the fascial planes causing necrotising fasciitis (NF), and can occasionally invade muscles causing a necrotising pyomyositis. A variety of microorganisms may be responsible and common pathogens under certain conditions and in certain hosts may become aggressive and invasive, resulting in skin death despite adequate treatment.

    A number of ‘hot topics’ on NSSTI were selected and reviewed by members of the Skin, Soft Tissue and Bone Infections Working Group of the International Society of Antimicrobial Chemotherapy (ISAC). This group includes international scientists, microbiology and infectious diseases clinicians and academics, whose aim is to advance the education and the science of infection management. This paper is an in-depth review of the current literature, providing a summary of the various NSSTI and expert opinions and insights from the authors’ own experience, highlighting areas for future study and research.
    Original languageEnglish
    Pages (from-to)1-10
    Number of pages10
    JournalInternational Journal of Antimicrobial Agents
    Volume52
    Issue number1
    Early online date6 Mar 2018
    DOIs
    Publication statusPublished - Jul 2018

    Fingerprint

    Soft Tissue Infections
    Skin
    Infection
    Pyomyositis
    Necrotizing Fasciitis
    Cellulitis
    Expert Testimony
    Microbiology
    Communicable Diseases
    Necrosis
    Morbidity
    Education
    Drug Therapy
    Muscles

    Cite this

    International Society of Antimicrobial Chemotherapy. / Hot topics in necrotising skin and soft tissue infections. In: International Journal of Antimicrobial Agents. 2018 ; Vol. 52, No. 1. pp. 1-10.
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    title = "Hot topics in necrotising skin and soft tissue infections",
    abstract = "Skin and soft tissue infections (SSTI) are amongst the most common infections encountered in clinical practice. Most infections do not result in skin or tissue necrosis; however, those that do are associated with a high mortality rate. In addition, because of the surreptitious presentation of the disease, clinical recognition is often delayed, resulting in rapid and overwhelming morbidity.Necrotising skin and soft tissue infections (NSSTI) are a spectrum of conditions and their presentation can vary depending on the host and microbial factors. NSSTI can spread in the superficial skin layers causing a necrotising cellulitis, or within deeper skin layers along the fascial planes causing necrotising fasciitis (NF), and can occasionally invade muscles causing a necrotising pyomyositis. A variety of microorganisms may be responsible and common pathogens under certain conditions and in certain hosts may become aggressive and invasive, resulting in skin death despite adequate treatment.A number of ‘hot topics’ on NSSTI were selected and reviewed by members of the Skin, Soft Tissue and Bone Infections Working Group of the International Society of Antimicrobial Chemotherapy (ISAC). This group includes international scientists, microbiology and infectious diseases clinicians and academics, whose aim is to advance the education and the science of infection management. This paper is an in-depth review of the current literature, providing a summary of the various NSSTI and expert opinions and insights from the authors’ own experience, highlighting areas for future study and research.",
    keywords = "Gas gangrene, Intravenous immunoglobulin G, Necrotising fasciitis, Panton-Valentine leukocidin, Pyomyositis, Skin and soft tissue infections",
    author = "{International Society of Antimicrobial Chemotherapy} and Kordo Saeed and Silvano Esposito and Ian Gould and Tiziana Ascione and Matteo Bassetti and Eric Bonnet and Emilio Bouza and Monica Chan and Davis, {Joshua S.} and {De Simone}, Giuseppe and Matthew Dryden and Thomas Gottlieb and Karolin Hijazi and Lye, {David C.} and Pasquale Pagliano and Christina Petridou and Elda Righi and John Segreti and Serhet Unal and Yalcin, {Ata Nevzat}",
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    Hot topics in necrotising skin and soft tissue infections. / International Society of Antimicrobial Chemotherapy.

    In: International Journal of Antimicrobial Agents, Vol. 52, No. 1, 07.2018, p. 1-10.

    Research output: Contribution to journalEditorialResearchpeer-review

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    T1 - Hot topics in necrotising skin and soft tissue infections

    AU - International Society of Antimicrobial Chemotherapy

    AU - Saeed, Kordo

    AU - Esposito, Silvano

    AU - Gould, Ian

    AU - Ascione, Tiziana

    AU - Bassetti, Matteo

    AU - Bonnet, Eric

    AU - Bouza, Emilio

    AU - Chan, Monica

    AU - Davis, Joshua S.

    AU - De Simone, Giuseppe

    AU - Dryden, Matthew

    AU - Gottlieb, Thomas

    AU - Hijazi, Karolin

    AU - Lye, David C.

    AU - Pagliano, Pasquale

    AU - Petridou, Christina

    AU - Righi, Elda

    AU - Segreti, John

    AU - Unal, Serhet

    AU - Yalcin, Ata Nevzat

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    N2 - Skin and soft tissue infections (SSTI) are amongst the most common infections encountered in clinical practice. Most infections do not result in skin or tissue necrosis; however, those that do are associated with a high mortality rate. In addition, because of the surreptitious presentation of the disease, clinical recognition is often delayed, resulting in rapid and overwhelming morbidity.Necrotising skin and soft tissue infections (NSSTI) are a spectrum of conditions and their presentation can vary depending on the host and microbial factors. NSSTI can spread in the superficial skin layers causing a necrotising cellulitis, or within deeper skin layers along the fascial planes causing necrotising fasciitis (NF), and can occasionally invade muscles causing a necrotising pyomyositis. A variety of microorganisms may be responsible and common pathogens under certain conditions and in certain hosts may become aggressive and invasive, resulting in skin death despite adequate treatment.A number of ‘hot topics’ on NSSTI were selected and reviewed by members of the Skin, Soft Tissue and Bone Infections Working Group of the International Society of Antimicrobial Chemotherapy (ISAC). This group includes international scientists, microbiology and infectious diseases clinicians and academics, whose aim is to advance the education and the science of infection management. This paper is an in-depth review of the current literature, providing a summary of the various NSSTI and expert opinions and insights from the authors’ own experience, highlighting areas for future study and research.

    AB - Skin and soft tissue infections (SSTI) are amongst the most common infections encountered in clinical practice. Most infections do not result in skin or tissue necrosis; however, those that do are associated with a high mortality rate. In addition, because of the surreptitious presentation of the disease, clinical recognition is often delayed, resulting in rapid and overwhelming morbidity.Necrotising skin and soft tissue infections (NSSTI) are a spectrum of conditions and their presentation can vary depending on the host and microbial factors. NSSTI can spread in the superficial skin layers causing a necrotising cellulitis, or within deeper skin layers along the fascial planes causing necrotising fasciitis (NF), and can occasionally invade muscles causing a necrotising pyomyositis. A variety of microorganisms may be responsible and common pathogens under certain conditions and in certain hosts may become aggressive and invasive, resulting in skin death despite adequate treatment.A number of ‘hot topics’ on NSSTI were selected and reviewed by members of the Skin, Soft Tissue and Bone Infections Working Group of the International Society of Antimicrobial Chemotherapy (ISAC). This group includes international scientists, microbiology and infectious diseases clinicians and academics, whose aim is to advance the education and the science of infection management. This paper is an in-depth review of the current literature, providing a summary of the various NSSTI and expert opinions and insights from the authors’ own experience, highlighting areas for future study and research.

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