HPV genotype prevalence in Australian women undergoing routine cervical screening by cytology status prior to implementation of an HPV vaccination program

Sepehr Tabrizi, Julia Brotherton, Matthew Stevens, John Condon, Peter McIntyre, David Smith, Suzanne Garland

    Research output: Contribution to journalArticle

    Abstract

    Background: Data on the prevalence of cervical HPV genotypes in Australia by age and by grade of cytological abnormality are sparse.

    Objective: 
    Measure prevalence of HPV genotypes among 2620 Australian women by age and cytology status.

    Study design: 
    Women presenting for routine Pap smear screening were recruited from diverse regions, including a significant sample of Indigenous women. DNA extracts prepared from Thinprep specimens were HPV genotyped by Roche LINEAR ARRAY HPV.

    Results: 
    HPV prevalence and genotype distribution were stratified by age (mean 32.6 y) and Pap smear result (cytology normal in 86.7%). Overall HPV prevalence was 38.7% with high-risk HPV prevalence of 26.5%. Prevalence of HPV (66.3% in women < 21 y to 15.3% in women > 40 y), multiple HPV infection (45.5% in <21 y to 5.8% in >40 y) and vaccine-targeted genotypes (HPV 6/11/16/18) (34.1% in <21 y to 2.4% in >40 y) declined significantly with age. The six most common genotypes were: HPV 16 (8.3%), 51 (5.1%), 53 (4.7%), 62 (4.3%), 89 (3.9%) and 52 (3.8%). HR-HPV prevalence increased from 21.1% in women with normal cytology to 80.9% in those with cytologically predicted high-grade abnormalities (HGAs) (p < 0.001). The most common genotypes in women with HGAs were HPV 16 (51.1%), 18 (14.9%), 52 (12.8%), 31 (10.6%), and 33 (10.6%): all HR-types.

    Conclusion: 
    Pre-vaccination cross-sectional prevalence of HR-HPV infection was high in this sample of Australian women attending for screening. HPV 16 was the commonest high-risk type detected at all ages and cytological grades.
    Original languageEnglish
    Pages (from-to)250-256
    Number of pages7
    JournalJournal of Clinical Virology
    Volume60
    Issue number3
    DOIs
    Publication statusPublished - Jul 2014

    Fingerprint Dive into the research topics of 'HPV genotype prevalence in Australian women undergoing routine cervical screening by cytology status prior to implementation of an HPV vaccination program'. Together they form a unique fingerprint.

    Cite this