Identification of molecular and immuno diagnostic cancer markers in the Northern Territory people

null Jagtar Singh; Rama Jayaraj; Siddartha Baxi; J Skinner; M Milava; Justin Curtin; Cameron Scott; Mahiban Thomas

Identification of molecular and immuno diagnostic cancer markers in the Northern Territory people

Jagtar Singh, Rama Jayaraj, Siddartha Baxi, J Skinner, M Milava, Justin Curtin, Cameron Scott, Mahiban Thomas

Research output: Other contribution - including Text-based ERA-eligible Creative Works › Other types of outputs

Abstract

Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of two years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

Original language	English
Number of pages	1
Publication status	Published - 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Identification of molecular and immuno diagnostic cancer markers in the Northern Territory people",

abstract = "Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of two years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.",

author = "{Jagtar Singh} and Rama Jayaraj and Siddartha Baxi and J Skinner and M Milava and Justin Curtin and Cameron Scott and Mahiban Thomas",

year = "2012",

language = "English",

type = "Other",

}

TY - GEN

T1 - Identification of molecular and immuno diagnostic cancer markers in the Northern Territory people

AU - Jagtar Singh, null

AU - Jayaraj, Rama

AU - Baxi, Siddartha

AU - Skinner, J

AU - Milava, M

AU - Curtin, Justin

AU - Scott, Cameron

AU - Thomas, Mahiban

PY - 2012

Y1 - 2012

N2 - Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of two years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

AB - Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of two years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

M3 - Other types of outputs

ER -

Identification of molecular and immuno diagnostic cancer markers in the Northern Territory people

Abstract

UN SDGs

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