Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population

R Jayaraj; Jagtar Singh; Justin Curtin; Cameron Scott; Marina Mileva; Mahiban Thomas

Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population

R Jayaraj, Jagtar Singh, Justin Curtin, Cameron Scott, Marina Mileva, Mahiban Thomas

Research output: Contribution to conference › Conference paper presented at Conference (not in Proceedings) › peer-review

Abstract

Purpose: Complete excision of cancer is guided by histological assessment of surgical margins. Molecular markers could be more sensitive to identify the malignant cells. P53 and eIF4E are found elevated 100% and 40-60% respectively in all head and neck squamous cell cancers (HNSCC). Over expression of these molecular markers in histologically tumour-free surgical margins correlated with a higher local-regional recurrence. Our aim is to study the expression and correlation of p53 and eIF4E on histologicaltumour free surgical margins and also to determine whether eIF4E is more sensitive marker than p53.
Patients and Methods: Immunohistochemical analysis was performed on surgical margins with antibodies to tumour prognostic markers (p53and eIF4E) of HNSCC patients who underwent surgical resection for their disease between March 2005 and December 2009 at Royal Darwin Hospital.
Results: Out of 24 HNSCC patients, 21(87%) patients have elevated levels of eIF4E and 13 (54%) patients have also elevated level of p53 in the tumours. There was a significant correlation between p53 and eIF4E being positive in the margins (P = 0.046). Chi-square test wasused to investigate the association between the expression of p53 and eIF4E and categorical variables like sex, age, Indigenous/non-Indigenous, TNM staging, and site of diagnosis respectively. The Kaplan-Meier curves wereused to investigate the survivability of head and neck cancer patients with over expression of p53and eIF4E on histological tumour free surgical margins.
Conclusion: The overexpression of eIF4E in the margins appears to be more sensitive indicator of recurrence.

Original language	English
Publication status	Published - 2012
Event	Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour - Brisbane Convention & Exhibition Centre, Brisbane, Australia Duration: 24 Oct 2012 → 26 Oct 2012

Conference

Conference	Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour
Abbreviated title	ANZHNCS Annual Scientific Meeting and IFHNOS 2012 World Tour
Country/Territory	Australia
City	Brisbane
Period	24/10/12 → 26/10/12

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jayaraj, R., Singh, J., Curtin, J., Scott, C., Mileva, M., & Thomas, M. (2012). Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population. Paper presented at Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour, Brisbane, Queensland, Australia.

@conference{68ecbeaa352944169a2592204746717a,

title = "Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population",

abstract = "Purpose: Complete excision of cancer is guided by histological assessment of surgical margins. Molecular markers could be more sensitive to identify the malignant cells. P53 and eIF4E are found elevated 100% and 40-60% respectively in all head and neck squamous cell cancers (HNSCC). Over expression of these molecular markers in histologically tumour-free surgical margins correlated with a higher local-regional recurrence. Our aim is to study the expression and correlation of p53 and eIF4E on histologicaltumour free surgical margins and also to determine whether eIF4E is more sensitive marker than p53.Patients and Methods: Immunohistochemical analysis was performed on surgical margins with antibodies to tumour prognostic markers (p53and eIF4E) of HNSCC patients who underwent surgical resection for their disease between March 2005 and December 2009 at Royal Darwin Hospital.Results: Out of 24 HNSCC patients, 21(87%) patients have elevated levels of eIF4E and 13 (54%) patients have also elevated level of p53 in the tumours. There was a significant correlation between p53 and eIF4E being positive in the margins (P = 0.046). Chi-square test wasused to investigate the association between the expression of p53 and eIF4E and categorical variables like sex, age, Indigenous/non-Indigenous, TNM staging, and site of diagnosis respectively. The Kaplan-Meier curves wereused to investigate the survivability of head and neck cancer patients with over expression of p53and eIF4E on histological tumour free surgical margins.Conclusion: The overexpression of eIF4E in the margins appears to be more sensitive indicator of recurrence.",

author = "R Jayaraj and Jagtar Singh and Justin Curtin and Cameron Scott and Marina Mileva and Mahiban Thomas",

year = "2012",

language = "English",

note = "Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour, ANZHNCS Annual Scientific Meeting and IFHNOS 2012 World Tour ; Conference date: 24-10-2012 Through 26-10-2012",

}

Jayaraj, R, Singh, J, Curtin, J, Scott, C, Mileva, M & Thomas, M 2012, 'Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population', Paper presented at Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour, Brisbane, Australia, 24/10/12 - 26/10/12.

Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population. / Jayaraj, R; Singh, Jagtar; Curtin, Justin et al.
2012. Paper presented at Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour, Brisbane, Queensland, Australia.

Research output: Contribution to conference › Conference paper presented at Conference (not in Proceedings) › peer-review

TY - CONF

T1 - Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population

AU - Jayaraj, R

AU - Singh, Jagtar

AU - Curtin, Justin

AU - Scott, Cameron

AU - Mileva, Marina

AU - Thomas, Mahiban

PY - 2012

Y1 - 2012

N2 - Purpose: Complete excision of cancer is guided by histological assessment of surgical margins. Molecular markers could be more sensitive to identify the malignant cells. P53 and eIF4E are found elevated 100% and 40-60% respectively in all head and neck squamous cell cancers (HNSCC). Over expression of these molecular markers in histologically tumour-free surgical margins correlated with a higher local-regional recurrence. Our aim is to study the expression and correlation of p53 and eIF4E on histologicaltumour free surgical margins and also to determine whether eIF4E is more sensitive marker than p53.Patients and Methods: Immunohistochemical analysis was performed on surgical margins with antibodies to tumour prognostic markers (p53and eIF4E) of HNSCC patients who underwent surgical resection for their disease between March 2005 and December 2009 at Royal Darwin Hospital.Results: Out of 24 HNSCC patients, 21(87%) patients have elevated levels of eIF4E and 13 (54%) patients have also elevated level of p53 in the tumours. There was a significant correlation between p53 and eIF4E being positive in the margins (P = 0.046). Chi-square test wasused to investigate the association between the expression of p53 and eIF4E and categorical variables like sex, age, Indigenous/non-Indigenous, TNM staging, and site of diagnosis respectively. The Kaplan-Meier curves wereused to investigate the survivability of head and neck cancer patients with over expression of p53and eIF4E on histological tumour free surgical margins.Conclusion: The overexpression of eIF4E in the margins appears to be more sensitive indicator of recurrence.

AB - Purpose: Complete excision of cancer is guided by histological assessment of surgical margins. Molecular markers could be more sensitive to identify the malignant cells. P53 and eIF4E are found elevated 100% and 40-60% respectively in all head and neck squamous cell cancers (HNSCC). Over expression of these molecular markers in histologically tumour-free surgical margins correlated with a higher local-regional recurrence. Our aim is to study the expression and correlation of p53 and eIF4E on histologicaltumour free surgical margins and also to determine whether eIF4E is more sensitive marker than p53.Patients and Methods: Immunohistochemical analysis was performed on surgical margins with antibodies to tumour prognostic markers (p53and eIF4E) of HNSCC patients who underwent surgical resection for their disease between March 2005 and December 2009 at Royal Darwin Hospital.Results: Out of 24 HNSCC patients, 21(87%) patients have elevated levels of eIF4E and 13 (54%) patients have also elevated level of p53 in the tumours. There was a significant correlation between p53 and eIF4E being positive in the margins (P = 0.046). Chi-square test wasused to investigate the association between the expression of p53 and eIF4E and categorical variables like sex, age, Indigenous/non-Indigenous, TNM staging, and site of diagnosis respectively. The Kaplan-Meier curves wereused to investigate the survivability of head and neck cancer patients with over expression of p53and eIF4E on histological tumour free surgical margins.Conclusion: The overexpression of eIF4E in the margins appears to be more sensitive indicator of recurrence.

UR - https://www.ohnng.com.au/documents/BRC_2012-03-30_ANZHNCS_ASM_Registration_Brochure.pdf

M3 - Conference paper presented at Conference (not in Proceedings)

T2 - Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour

Y2 - 24 October 2012 through 26 October 2012

ER -

Jayaraj R, Singh J, Curtin J, Scott C, Mileva M, Thomas M. Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population. 2012. Paper presented at Australian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour, Brisbane, Queensland, Australia.

Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population

Abstract

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