Identification of molecular and immuno diagnostic cancer markers in Northern Territory Indigenous population

R Jayaraj, Jagtar Singh, Justin Curtin, Cameron Scott, Marina Mileva, Mahiban Thomas

    Research output: Contribution to conferenceConference paper presented at Conference (not in Proceedings)peer-review

    Abstract

    Purpose: Complete excision of cancer is guided by histological assessment of surgical margins. Molecular markers could be more sensitive to identify the malignant cells. P53 and eIF4E are found elevated 100% and 40-60% respectively in all head and neck squamous cell cancers (HNSCC). Over expression of these molecular markers in histologically tumour-free surgical margins correlated with a higher local-regional recurrence. Our aim is to study the expression and correlation of p53 and eIF4E on histologicaltumour free surgical margins and also to determine whether eIF4E is more sensitive marker than p53.
    Patients and Methods: Immunohistochemical analysis was performed on surgical margins with antibodies to tumour prognostic markers (p53and eIF4E) of HNSCC patients who underwent surgical resection for their disease between March 2005 and December 2009 at Royal Darwin Hospital.
    Results: Out of 24 HNSCC patients, 21(87%) patients have elevated levels of eIF4E and 13 (54%) patients have also elevated level of p53 in the tumours. There was a significant correlation between p53 and eIF4E being positive in the margins (P = 0.046). Chi-square test wasused to investigate the association between the expression of p53 and eIF4E and categorical variables like sex, age, Indigenous/non-Indigenous, TNM staging, and site of diagnosis respectively. The Kaplan-Meier curves wereused to investigate the survivability of head and neck cancer patients with over expression of p53and eIF4E on histological tumour free surgical margins.
    Conclusion: The overexpression of eIF4E in the margins appears to be more sensitive indicator of recurrence.
    Original languageEnglish
    Publication statusPublished - 2012
    EventAustralian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour - Brisbane Convention & Exhibition Centre, Brisbane, Australia
    Duration: 24 Oct 201226 Oct 2012

    Conference

    ConferenceAustralian and New Zealand Head and Neck Cancer Society Annual Meeting and International Federation of Head and Neck Oncologist Society 2012 World Tour
    Abbreviated titleANZHNCS Annual Scientific Meeting and IFHNOS 2012 World Tour
    CountryAustralia
    CityBrisbane
    Period24/10/1226/10/12

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