Identification of molecular and immuno-diagnostic cancer markers in Northern Territory Australian Indigenous population

Mahiban Thomas; null Jagtar Singh; Isabelle Lys; George Car; Marina Mileva; Siddartha Baxi; Rama Jayaraj

doi:10.1016/j.oraloncology.2011.06.313

Identification of molecular and immuno-diagnostic cancer markers in Northern Territory Australian Indigenous population

Mahiban Thomas, Jagtar Singh, Isabelle Lys, George Car, Marina Mileva, Siddartha Baxi, Rama Jayaraj

Research output: Contribution to journal › Comment/debate

Abstract

Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of 2 years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

Original language	English
Article number	P70
Pages (from-to)	s96
Number of pages	1
Journal	Oral Oncology
Volume	47
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/j.oraloncology.2011.06.313
Publication status	Published - Jul 2011

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title = "Identification of molecular and immuno-diagnostic cancer markers in Northern Territory Australian Indigenous population",

abstract = "Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of 2 years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.",

author = "Mahiban Thomas and {Jagtar Singh} and Isabelle Lys and George Car and Marina Mileva and Siddartha Baxi and Rama Jayaraj",

year = "2011",

month = jul,

doi = "10.1016/j.oraloncology.2011.06.313",

language = "English",

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pages = "s96",

journal = "Oral Oncology",

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T1 - Identification of molecular and immuno-diagnostic cancer markers in Northern Territory Australian Indigenous population

AU - Thomas, Mahiban

AU - Jagtar Singh, null

AU - Lys, Isabelle

AU - Car, George

AU - Mileva, Marina

AU - Baxi, Siddartha

AU - Jayaraj, Rama

PY - 2011/7

Y1 - 2011/7

N2 - Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of 2 years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

AB - Head and neck cancer have high local recurrence rates when tumour resection is incomplete. The choice of management if a margin is positive or close is wider surgical resection. We postulate that genetic changes precede gross histological alterations; hence use of molecular markers (4E and P53) to establish surgical margins may decrease the local recurrence and improve clinical outcomes. We studied E4 and P53 at the margins of resected mucosal lesions of the oro-pharynx of lesions reported employing histopathology alone at the RDH from March 2005 to March 2009. These results were co-related with the clinical outcomes of these patients, ensuring a minimum follow up of 2 years, and an assessment made of the effectiveness of the two immunohistochemical markers. We also compare the efficacy of E4 and P53 as predictors of negative prognosis.

U2 - 10.1016/j.oraloncology.2011.06.313

DO - 10.1016/j.oraloncology.2011.06.313

M3 - Comment/debate

SN - 1368-8375

VL - 47

SP - s96

JO - Oral Oncology

JF - Oral Oncology

IS - Supplement 1

M1 - P70

ER -

Identification of molecular and immuno-diagnostic cancer markers in Northern Territory Australian Indigenous population

Abstract

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