Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population

Amanda Leach, Peter Morris, Grant Mackenzie, J McDonnell, Anne Balloch, Jonathan Carapetis, Mimi Tang

    Research output: Contribution to journalArticle

    Abstract

    Background: A unique schedule of 7-valent pneumococcal conjugate vaccine (7PCV) at 2, 4 and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months commenced for Australian Aboriginal infants in 2001. Methods: Anti-capsular IgG concentrations in vaccinated and non-vaccinated (historic control) infants were determined (blinded) by (22F absorbed) ELISA. Results: One month after dose 3 of 7PCV, geometric mean concentrations (GMCs) were >1.95 ?g/ml and at least 89% of infants had IgG >0.35 ?g/ml to all 7PCV serotypes. One month post-23PPV, IgG to 7PCV serotypes was >0.35 ?g/ml for more than 96% infants (>1.3 ?g/ml for at least 70%), and IgG to non-7PCV serotypes was >0.35 ?g/ml for more than 50% infants (including serotype 6A, but not 12F (17%) or 19A (44%). Conclusion: 7PCV and 23PPV are immunogenic in this population. � 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)3885-3891
    Number of pages7
    JournalVaccine
    Volume26
    Issue number31
    Publication statusPublished - 2008

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    Leach, A., Morris, P., Mackenzie, G., McDonnell, J., Balloch, A., Carapetis, J., & Tang, M. (2008). Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population. Vaccine, 26(31), 3885-3891.