Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

Nusrat Homaira, Nancy Briggs, Ju Lee Oei, Lisa Hilder, Barbara Bajuk, Tom Snelling, Georgina M. Chambers, Adam Jaffe

    Research output: Contribution to journalArticleResearchpeer-review

    10 Downloads (Pure)

    Abstract

    Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.

    Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights.

    Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without.

    Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

    Original languageEnglish
    Pages (from-to)233-239
    Number of pages7
    JournalInfluenza and Other Respiratory Viruses
    Volume13
    Issue number3
    Early online date30 Jan 2019
    DOIs
    Publication statusPublished - May 2019

    Fingerprint

    Human Influenza
    Lung Diseases
    Hospitalization
    Chronic Disease
    Bronchopulmonary Dysplasia
    Cystic Fibrosis
    Incidence
    Asthma
    Costs and Cost Analysis
    Lung
    South Australia
    New South Wales
    Hospital Costs
    Public Hospitals
    Population
    Cohort Studies

    Cite this

    Homaira, N., Briggs, N., Oei, J. L., Hilder, L., Bajuk, B., Snelling, T., ... Jaffe, A. (2019). Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. Influenza and Other Respiratory Viruses, 13(3), 233-239. https://doi.org/10.1111/irv.12633
    Homaira, Nusrat ; Briggs, Nancy ; Oei, Ju Lee ; Hilder, Lisa ; Bajuk, Barbara ; Snelling, Tom ; Chambers, Georgina M. ; Jaffe, Adam. / Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. In: Influenza and Other Respiratory Viruses. 2019 ; Vol. 13, No. 3. pp. 233-239.
    @article{b6ee38423d364855b08134aa34176afa,
    title = "Impact of influenza on hospitalization rates in children with a range of chronic lung diseases",
    abstract = "Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2{\%}) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95{\%} CI: 2.6-5.2) and 0.7 (95{\%} CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95{\%} CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95{\%} CI) of influenza-associated hospitalization was AUD 19 704 (95{\%} CI: 11 715-27 693) for children with CLDs compared to 4557 (95{\%} CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.",
    keywords = "chronic lung diseases, influenza burden, pediatrics",
    author = "Nusrat Homaira and Nancy Briggs and Oei, {Ju Lee} and Lisa Hilder and Barbara Bajuk and Tom Snelling and Chambers, {Georgina M.} and Adam Jaffe",
    year = "2019",
    month = "5",
    doi = "10.1111/irv.12633",
    language = "English",
    volume = "13",
    pages = "233--239",
    journal = "Influenza and Other Respiratory Viruses",
    issn = "1750-2640",
    publisher = "Wiley-Blackwell",
    number = "3",

    }

    Homaira, N, Briggs, N, Oei, JL, Hilder, L, Bajuk, B, Snelling, T, Chambers, GM & Jaffe, A 2019, 'Impact of influenza on hospitalization rates in children with a range of chronic lung diseases', Influenza and Other Respiratory Viruses, vol. 13, no. 3, pp. 233-239. https://doi.org/10.1111/irv.12633

    Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. / Homaira, Nusrat; Briggs, Nancy; Oei, Ju Lee; Hilder, Lisa; Bajuk, Barbara; Snelling, Tom; Chambers, Georgina M.; Jaffe, Adam.

    In: Influenza and Other Respiratory Viruses, Vol. 13, No. 3, 05.2019, p. 233-239.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

    AU - Homaira, Nusrat

    AU - Briggs, Nancy

    AU - Oei, Ju Lee

    AU - Hilder, Lisa

    AU - Bajuk, Barbara

    AU - Snelling, Tom

    AU - Chambers, Georgina M.

    AU - Jaffe, Adam

    PY - 2019/5

    Y1 - 2019/5

    N2 - Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

    AB - Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

    KW - chronic lung diseases

    KW - influenza burden

    KW - pediatrics

    UR - http://www.scopus.com/inward/record.url?scp=85064519180&partnerID=8YFLogxK

    U2 - 10.1111/irv.12633

    DO - 10.1111/irv.12633

    M3 - Article

    VL - 13

    SP - 233

    EP - 239

    JO - Influenza and Other Respiratory Viruses

    JF - Influenza and Other Respiratory Viruses

    SN - 1750-2640

    IS - 3

    ER -