Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

Nusrat Homaira, Nancy Briggs, Ju Lee Oei, Lisa Hilder, Barbara Bajuk, Tom Snelling, Georgina M. Chambers, Adam Jaffe

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Abstract

Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.

Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights.

Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without.

Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalInfluenza and Other Respiratory Viruses
Volume13
Issue number3
Early online date30 Jan 2019
DOIs
Publication statusPublished - May 2019

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Human Influenza
Lung Diseases
Hospitalization
Chronic Disease
Bronchopulmonary Dysplasia
Cystic Fibrosis
Incidence
Asthma
Costs and Cost Analysis
Lung
South Australia
New South Wales
Hospital Costs
Public Hospitals
Population
Cohort Studies

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Homaira, N., Briggs, N., Oei, J. L., Hilder, L., Bajuk, B., Snelling, T., ... Jaffe, A. (2019). Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. Influenza and Other Respiratory Viruses, 13(3), 233-239. https://doi.org/10.1111/irv.12633
Homaira, Nusrat ; Briggs, Nancy ; Oei, Ju Lee ; Hilder, Lisa ; Bajuk, Barbara ; Snelling, Tom ; Chambers, Georgina M. ; Jaffe, Adam. / Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. In: Influenza and Other Respiratory Viruses. 2019 ; Vol. 13, No. 3. pp. 233-239.
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abstract = "Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2{\%}) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95{\%} CI: 2.6-5.2) and 0.7 (95{\%} CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95{\%} CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95{\%} CI) of influenza-associated hospitalization was AUD 19 704 (95{\%} CI: 11 715-27 693) for children with CLDs compared to 4557 (95{\%} CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.",
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Homaira, N, Briggs, N, Oei, JL, Hilder, L, Bajuk, B, Snelling, T, Chambers, GM & Jaffe, A 2019, 'Impact of influenza on hospitalization rates in children with a range of chronic lung diseases', Influenza and Other Respiratory Viruses, vol. 13, no. 3, pp. 233-239. https://doi.org/10.1111/irv.12633

Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. / Homaira, Nusrat; Briggs, Nancy; Oei, Ju Lee; Hilder, Lisa; Bajuk, Barbara; Snelling, Tom; Chambers, Georgina M.; Jaffe, Adam.

In: Influenza and Other Respiratory Viruses, Vol. 13, No. 3, 05.2019, p. 233-239.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

AU - Homaira, Nusrat

AU - Briggs, Nancy

AU - Oei, Ju Lee

AU - Hilder, Lisa

AU - Bajuk, Barbara

AU - Snelling, Tom

AU - Chambers, Georgina M.

AU - Jaffe, Adam

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N2 - Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

AB - Background: Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. Method: We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Results: Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without. Discussion: This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

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