Impaired systemic production of prostaglandin E2 in children with cerebral malaria

D Perkins, J Hittner, Esther Mwaikambo, D GRANGER, J WEINBERG, Nicholas Anstey

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Prostaglandins (PGs) are important mediators of macrophage activity, vascular permeability, fever, erythropoiesis, and proinflammatory responses to infection. Our recent studies have shown that plasma levels of bicyclo-PGE 2 (a stable end product of PGE2 metabolism) and leukocyte cyclooxygenase (COX)-2 gene expression are suppressed in children with malarial anemia. Since the role of PGs as immunomodulators of human cerebral malaria (CM) has not been examined, we investigated urinary levels of bicyclo-PGE 2/creatinine in children with varying clinical outcomes of CM. Among parasitemic children, those with asymptomatic parasitemia had the highest levels of bicyclo-PGE2/creatinine, whereas those with CM had significantly lower levels of bicyclo-PGE2. Systemic levels of bicyclo-PGE 2/creatinine were not significantly associated with parasitemia, hemoglobin levels, or levels of the PG-regulatory cytokine tumor necrosis factor-? but were positively correlated with levels of interleukin-10. The results presented here show that impaired systemic production of PGE 2 is associated with adverse outcomes of CM, whereas elevated levels of PGE2 in asymptomatic parasitemia suggest a potential role for PGs in protective immunity. � 2005 by the Infectious Diseases Society of America. All rights reserved.
    Original languageEnglish
    Pages (from-to)1548-1557
    Number of pages10
    JournalJournal of Infectious Diseases
    Volume191
    Issue number9
    Publication statusPublished - 2005

    Fingerprint

    Cerebral Malaria
    Prostaglandins E
    Dinoprostone
    Prostaglandins
    Parasitemia
    Creatinine
    Erythropoiesis
    Immunologic Factors
    Capillary Permeability
    Cyclooxygenase 2
    Interleukin-10
    Anemia
    Immunity
    Hemoglobins
    Leukocytes
    Fever
    Tumor Necrosis Factor-alpha
    Macrophages
    Cytokines
    Gene Expression

    Cite this

    Perkins, D., Hittner, J., Mwaikambo, E., GRANGER, D., WEINBERG, J., & Anstey, N. (2005). Impaired systemic production of prostaglandin E2 in children with cerebral malaria. Journal of Infectious Diseases, 191(9), 1548-1557.
    Perkins, D ; Hittner, J ; Mwaikambo, Esther ; GRANGER, D ; WEINBERG, J ; Anstey, Nicholas. / Impaired systemic production of prostaglandin E2 in children with cerebral malaria. In: Journal of Infectious Diseases. 2005 ; Vol. 191, No. 9. pp. 1548-1557.
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    Perkins, D, Hittner, J, Mwaikambo, E, GRANGER, D, WEINBERG, J & Anstey, N 2005, 'Impaired systemic production of prostaglandin E2 in children with cerebral malaria', Journal of Infectious Diseases, vol. 191, no. 9, pp. 1548-1557.

    Impaired systemic production of prostaglandin E2 in children with cerebral malaria. / Perkins, D; Hittner, J; Mwaikambo, Esther; GRANGER, D; WEINBERG, J; Anstey, Nicholas.

    In: Journal of Infectious Diseases, Vol. 191, No. 9, 2005, p. 1548-1557.

    Research output: Contribution to journalArticleResearchpeer-review

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    Perkins D, Hittner J, Mwaikambo E, GRANGER D, WEINBERG J, Anstey N. Impaired systemic production of prostaglandin E2 in children with cerebral malaria. Journal of Infectious Diseases. 2005;191(9):1548-1557.