TY - JOUR
T1 - In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum
AU - Thriemer, Kamala
AU - Wernsdorfer, Gunther
AU - Rojanawatsirivet, Chaiporn
AU - Kollaritsch, Herwig
AU - Sirichainsinthop, Jeeraphat
AU - Wernsdorfer, Walther H.
PY - 2005/10
Y1 - 2005/10
N2 - Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.
AB - Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.
KW - Artemisinin
KW - In vitro
KW - Plasmodium falciparum
KW - Retinol
KW - Synergism
UR - http://www.scopus.com/inward/record.url?scp=33644841954&partnerID=8YFLogxK
U2 - 10.1007/s00508-005-0447-3
DO - 10.1007/s00508-005-0447-3
M3 - Article
C2 - 16416385
AN - SCOPUS:33644841954
VL - 117
SP - 45
EP - 48
JO - Wiener Klinische Wochenschrift
JF - Wiener Klinische Wochenschrift
SN - 0043-5325
IS - SUPPL. 4
ER -