In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum

Kamala Thriemer; Gunther Wernsdorfer; Chaiporn Rojanawatsirivet; Herwig Kollaritsch; Jeeraphat Sirichainsinthop; Walther H. Wernsdorfer

doi:10.1007/s00508-005-0447-3

In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum

Kamala Thriemer, Gunther Wernsdorfer, Chaiporn Rojanawatsirivet, Herwig Kollaritsch, Jeeraphat Sirichainsinthop, Walther H. Wernsdorfer

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Wiener Klinische Wochenschrift
Volume	117
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1007/s00508-005-0447-3
Publication status	Published - Oct 2005
Externally published	Yes

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title = "In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum",

abstract = "Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.",

keywords = "Artemisinin, In vitro, Plasmodium falciparum, Retinol, Synergism",

author = "Kamala Thriemer and Gunther Wernsdorfer and Chaiporn Rojanawatsirivet and Herwig Kollaritsch and Jeeraphat Sirichainsinthop and Wernsdorfer, {Walther H.}",

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AU - Thriemer, Kamala

AU - Wernsdorfer, Gunther

AU - Rojanawatsirivet, Chaiporn

AU - Kollaritsch, Herwig

AU - Sirichainsinthop, Jeeraphat

AU - Wernsdorfer, Walther H.

PY - 2005/10

Y1 - 2005/10

N2 - Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.

AB - Increasing resistance of Plasmodium falciparum to antimalarial drugs is an important public health problem, demanding novel therapeutic approaches. This study had the objective of assessing the in vitro activity of artemisinin and its combination with retinol in fresh isolates of P. falciparum in an area with a high proportion of multi-drug resistant strains. The tests were based on the inhibition of schizont maturation. In 45 successfully tested isolates, the mean effective concentrations (ECs) of artemisinin were 10.29 nM for the EC50 and 34.86 nM for the EC90. The EC50 and EC90 for artemisinin in the artemisinin- retinol mixture were 2.71 nM and 13.37 nM , respectively. The combination showed synergistic activity. Retinol appears to be a promising partner for the antimalarial therapy with artemisinins.

KW - Artemisinin

KW - In vitro

KW - Plasmodium falciparum

KW - Retinol

KW - Synergism

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VL - 117

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JF - Wiener Klinische Wochenschrift

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ER -

In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum

Abstract

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