In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol)

Ross A Kennedy, Michelle Kennedy, Hana Morrissey, Patrick Ball

    Research output: Contribution to journalArticle

    Abstract

    Recent evidence has shown improved outcomes in pediatric intensive care units with the intensive use of intravenous in-line filtration. This has caused resurgence in interest in filter use but has raised questions in relation
    to emulsion-based formulations such as propofol. Our objective was to test two propofol products, Diprivan® and Fresofol®, with the Pall Lipipor® TNA and Lipipor NLF intravenous in-line filters and to assay the content before and
    after filtration under typical infusion conditions. The propofol emulsions were delivered from a 50 mL syringe through an extension set and into either a Lipipor TNA (50 mL/h–1) or Lipipor NLF (20 mL/h–1) filter. Samples were
    taken at regular intervals and assayed using a high-performance liquid chromatography method before and after filtration. No evidence was found of a significant concentration change during passage of either product through either model of filter. Propofol from two products was found to pass through two different types of Pall 1.2 m intravenous in-line filters. There was no significant change in concentration before and after filtration under typical conditions of administration. In conclusion, administration of these products through these models of in-line filter would be safe and effective.
    Original languageEnglish
    Pages (from-to)297-306
    Number of pages10
    JournalPDA Journal of Pharmaceutical Science and Technology
    Volume69
    Issue number2
    DOIs
    Publication statusPublished - 2015

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