In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol)

Recent evidence has shown improved outcomes in pediatric intensive care units with the intensive use of intravenous in-line filtration. This has caused resurgence in interest in filter use but has raised questions in relation
to emulsion-based formulations such as propofol. Our objective was to test two propofol products, Diprivan® and Fresofol®, with the Pall Lipipor® TNA and Lipipor NLF intravenous in-line filters and to assay the content before and
after filtration under typical infusion conditions. The propofol emulsions were delivered from a 50 mL syringe through an extension set and into either a Lipipor TNA (50 mL/h–1) or Lipipor NLF (20 mL/h–1) filter. Samples were
taken at regular intervals and assayed using a high-performance liquid chromatography method before and after filtration. No evidence was found of a significant concentration change during passage of either product through either model of filter. Propofol from two products was found to pass through two different types of Pall 1.2 m intravenous in-line filters. There was no significant change in concentration before and after filtration under typical conditions of administration. In conclusion, administration of these products through these models of in-line filter would be safe and effective.