In Vitro Anticancer Activity of Nanoformulated Mono- and Di-nuclear Pt Compounds

Pan Wang, Jian Wei Wang, Wen Hua Zhang, Hongzhen Bai, Guping Tang, David J. Young

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoformulations of mononuclear Pt complexes cis-PtCl2(PPh3)2 (1), [Pt(PPh3)2(L−Cys)] ⋅ H2O (3, L−Cys=L-cysteinate), trans-PtCl2(PPh2PhNMe2)2 (4; PPh2PhNMe2=4-(dimethylamine)triphenylphosphine), trans-PtI2(PPh2PhNMe2)2 (5) and dinuclear Pt cluster Pt2(μ-S)2(PPh3)4 (2) have comparable cytotoxicity to cisplatin against murine melanoma cell line B16F10. Masking of these discrete molecular entities within the hydrophobic core of Pluronic® F-127 significantly boosted their solubility and stability, ensuring efficient cellular uptake, giving in vitro IC50 values in the range of 0.87–11.23 μM. These results highlight the potential therapeutic value of Pt complexes featuring stable Pt−P bonds in nanocomposite formulations with biocompatible amphiphilic polymers.

Original languageEnglish
Number of pages9
JournalChemistry - An Asian Journal
DOIs
Publication statusE-pub ahead of print - 12 Aug 2021

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