In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines

Ava Bachari; Nazim Nassar; Srinivasareddy Telukutla; Roby Zomer; Chaitali Dekiwadia; Terrence J. Piva; Nitin Mantri

doi:10.3390/cells12202450

In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines

Ava Bachari, Nazim Nassar, Srinivasareddy Telukutla, Roby Zomer, Chaitali Dekiwadia, Terrence J. Piva, Nitin Mantri

Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely recognized to resist advanced cancer treatments, including immune checkpoint inhibitors, kinase inhibitors, and chemotherapy. Numerous studies have shown that various Cannabis sativa extracts exhibit potential anticancer effects against different types of tumours both in vitro and in vivo. This study is the first to report that PHEC-66, a Cannabis sativa extract, displays antiproliferative effects against MM418-C1, MM329 and MM96L melanoma cells. Although these findings suggest that PHEC-66 has promising potential as a pharmacotherapeutic agent for melanoma treatment, further research is necessary to evaluate its safety, efficacy, and clinical applications.

Original language	English
Article number	2450
Pages (from-to)	1-17
Number of pages	17
Journal	Cells
Volume	12
Issue number	20
DOIs	https://doi.org/10.3390/cells12202450
Publication status	Published - Oct 2023

Bibliographical note

Funding Information:
This research was funded by MGC Pharmaceuticals Ltd., Australia through grant number RE-03103. A.B. received Ph.D. scholarship from RMIT University, Australia.

Publisher Copyright:
© 2023 by the authors.

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10.3390/cells12202450

89285943-oaFinal published version, 2.96 MBLicence: CC BY

Cite this

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title = "In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines",

abstract = "Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely recognized to resist advanced cancer treatments, including immune checkpoint inhibitors, kinase inhibitors, and chemotherapy. Numerous studies have shown that various Cannabis sativa extracts exhibit potential anticancer effects against different types of tumours both in vitro and in vivo. This study is the first to report that PHEC-66, a Cannabis sativa extract, displays antiproliferative effects against MM418-C1, MM329 and MM96L melanoma cells. Although these findings suggest that PHEC-66 has promising potential as a pharmacotherapeutic agent for melanoma treatment, further research is necessary to evaluate its safety, efficacy, and clinical applications.",

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author = "Ava Bachari and Nazim Nassar and Srinivasareddy Telukutla and Roby Zomer and Chaitali Dekiwadia and Piva, {Terrence J.} and Nitin Mantri",

note = "Funding Information: This research was funded by MGC Pharmaceuticals Ltd., Australia through grant number RE-03103. A.B. received Ph.D. scholarship from RMIT University, Australia. Publisher Copyright: {\textcopyright} 2023 by the authors.",

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doi = "10.3390/cells12202450",

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AU - Bachari, Ava

AU - Nassar, Nazim

AU - Telukutla, Srinivasareddy

AU - Zomer, Roby

AU - Dekiwadia, Chaitali

AU - Piva, Terrence J.

AU - Mantri, Nitin

N1 - Funding Information: This research was funded by MGC Pharmaceuticals Ltd., Australia through grant number RE-03103. A.B. received Ph.D. scholarship from RMIT University, Australia. Publisher Copyright: © 2023 by the authors.

PY - 2023/10

Y1 - 2023/10

N2 - Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely recognized to resist advanced cancer treatments, including immune checkpoint inhibitors, kinase inhibitors, and chemotherapy. Numerous studies have shown that various Cannabis sativa extracts exhibit potential anticancer effects against different types of tumours both in vitro and in vivo. This study is the first to report that PHEC-66, a Cannabis sativa extract, displays antiproliferative effects against MM418-C1, MM329 and MM96L melanoma cells. Although these findings suggest that PHEC-66 has promising potential as a pharmacotherapeutic agent for melanoma treatment, further research is necessary to evaluate its safety, efficacy, and clinical applications.

AB - Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely recognized to resist advanced cancer treatments, including immune checkpoint inhibitors, kinase inhibitors, and chemotherapy. Numerous studies have shown that various Cannabis sativa extracts exhibit potential anticancer effects against different types of tumours both in vitro and in vivo. This study is the first to report that PHEC-66, a Cannabis sativa extract, displays antiproliferative effects against MM418-C1, MM329 and MM96L melanoma cells. Although these findings suggest that PHEC-66 has promising potential as a pharmacotherapeutic agent for melanoma treatment, further research is necessary to evaluate its safety, efficacy, and clinical applications.

KW - C. sativa

KW - cannabinoids

KW - melanoma

KW - PHEC-66

KW - skin cancer

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JF - Cells

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M1 - 2450

ER -

In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines

Abstract

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