In vitro interaktionsstudien mit azithromycin und dihydroartemisinin in Plasmodium falciparum isolaten aus Bangladesh

Translated title of the contribution: In vitro interaction studies of azithromycin and dihydroartemisinin in Plasmodium falciparum isolates from Bangladesh

Matthias G. Vossen, Rashidul Haque, Peter Starzengruber, Wasif Ali Khan, Kamala Thriemer, Aung Swi Prue Marma, Selim Akther, Mark Fukuda, Harald Noedl

Research output: Contribution to journalArticle

Abstract

In recent clinical trials acithromycin in combination with artemisinin derivatives proved to be a promising combination therapy with indifferent to synergistic interaction. The aim of the present study was the assessment of optimal combination ratios for dihydroartemisinin and azithromycin for the treatment of uncomplicated falciparum malaria. The study was conducted in Bandarban, in Southeastern Bangladesh. Plasmodium falciparum isolates collected as part of a clinical trial were cultured for 72 hours. Samples were analyzed using the HRP2 drug sensitivity assay in fixed combinations and checkerboard assays. An indifferent mode of interaction was found for the 1: 500 combination of dihydroartemisinine and azithromycin. The sum fractional inhibitory concentrations (SFICs) at IC95 ranged from 0.89 to 1.16 for combination ratios of 1: 500 and 1: 5000, respectively. A trend towards lower SFICs was observed with rising inhibitory concentrations (i.e. at IC90 and IC95). Correlation analysis suggests a different mode of action for azithromycin as compared to traditional antimalarials.

Translated title of the contributionIn vitro interaction studies of azithromycin and dihydroartemisinin in Plasmodium falciparum isolates from Bangladesh
Original languageGerman
Pages (from-to)71-75
Number of pages5
JournalWiener Klinische Wochenschrift
Volume119
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 1 Jan 2007
Externally publishedYes

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