@article{e168be773b3c402199c8b4cae05690f2,
title = "In vivo parasitological measures of artemisinin susceptibility",
abstract = "Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites//?L given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. � 2010 by the Infectious Diseases Society of America. All rights reserved.",
keywords = "amodiaquine, antibiotic agent, artemether, artemisinin, artemisinin derivative, artesunate, atovaquone plus proguanil, benflumetol, chloroquine, clindamycin, dihydroartemisinin, doxycycline, fansidar, mefloquine, piperaquine, primaquine, quinine, tetracycline, trimethoprim, adolescent, article, blood smear, child, drug dose regimen, drug sensitivity, drug treatment failure, hospital admission, human, in vivo study, major clinical study, malaria falciparum, parasitology, predictor variable, preschool child, priority journal, school child, screening, treatment duration, Adolescent, Adult, Aged, Aged, 80 and over, Antimalarials, Artemisinins, Child, Child, Preschool, Drug Resistance, Endemic Diseases, Humans, Infant, Kaplan-Meiers Estimate, Malaria, Falciparum, Middle Aged, Parasitemia, Plasmodium falciparum, Recurrence",
author = "Kasia Stepniewska and Elizabeth Ashley and Lee, {Sue J} and Nicholas Anstey and Barnes, {Karen I} and Binh, {Tran Quang} and Umberto D'Alessandro and Nicholas Day and {De Vries}, Peter and Grant Dorsey and Jean-Paul Guthmann and Mayfong Mayxay and Newton, {Paul N} and Piero Olliaro and Lyda Osorio and Ric Price and Mark Rowland and Frank Smithuis and Taylor, {Walter R J} and Fran{\~A}§ois Nosten and White, {Nicholas J}",
year = "2010",
language = "English",
volume = "201",
pages = "570--579",
journal = "The Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
}