In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study

Amanda Leach; Peter Morris; Heidi Smith-Vaughan; John D. Mathews

doi:10.1128/AAC.46.11.3648-3649.2002

In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study

Amanda Leach, Peter Morris, Heidi Smith-Vaughan, John D. Mathews

Research output: Contribution to journal › Comment/debate

Abstract

This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics

Original language	English
Pages (from-to)	3648-3649
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	11
DOIs	https://doi.org/10.1128/AAC.46.11.3648-3649.2002
Publication status	Published - 2002

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10.1128/AAC.46.11.3648-3649.2002

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Leach, A., Morris, P., Smith-Vaughan, H., & Mathews, J. D. (2002). In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study. Antimicrobial Agents and Chemotherapy, 46(11), 3648-3649. https://doi.org/10.1128/AAC.46.11.3648-3649.2002

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abstract = "This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics",

keywords = "Australia, Infant, Lung, Penicillins, Pneumonia, Pneumococcal, Streptococcus",

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Leach, A , Morris, P , Smith-Vaughan, H & Mathews, JD 2002, 'In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study', Antimicrobial Agents and Chemotherapy, vol. 46, no. 11, pp. 3648-3649. https://doi.org/10.1128/AAC.46.11.3648-3649.2002

In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease : a case study. / Leach, Amanda ; Morris, Peter ; Smith-Vaughan, Heidi et al.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 11, 2002, p. 3648-3649.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease

T2 - a case study

AU - Leach, Amanda

AU - Morris, Peter

AU - Smith-Vaughan, Heidi

AU - Mathews, John D.

PY - 2002

Y1 - 2002

N2 - This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics

AB - This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics

KW - Australia

KW - Infant

KW - Lung

KW - Penicillins

KW - Pneumonia

KW - Pneumococcal

KW - Streptococcus

U2 - 10.1128/AAC.46.11.3648-3649.2002

DO - 10.1128/AAC.46.11.3648-3649.2002

M3 - Comment/debate

VL - 46

SP - 3648

EP - 3649

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 11

ER -

In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study

Abstract

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