Abstract
Objective: To determine the incidence of childhood onset type 1 diabetes in Australia from 2002 to 2017, and analyze incidence rate trends by calendar year, sex, and age at diagnosis. Research Design and Methods: Children newly diagnosed with type 1 diabetes aged <15 years between 2002 and 2017 were identified from the National Diabetes Register, estimated to be ~99% complete. Data were obtained for diagnosis year, sex, age, and residential State/Territory at time of diagnosis. Population estimates by year, sex, single year of age, and State/Territory were obtained from the Australian Bureau of Statistics and Poisson regression used to examine incidence and trends by calendar year, sex, and age group at diagnosis. Results: Between 2002 and 2017, there were 16 783 newly diagnosed cases of type 1 diabetes in children aged < 15 years (8684 boys: 8099 girls), giving a mean incidence of 25.0/1 00 000 person years (95%CI: 24.6, 25.4). A sinusoidal pattern in the incidence rate trend was observed with 5-yearly cycles providing the best model fit. No significant difference was observed in boys compared to girls (IRR 0.98 [95%CI: 0.95, 1.01]). Compared to 0 to 4 year olds, the mean incidence was 75% higher in 5 to 9 year olds, and 224% higher in 10 to 14 year olds. A decreasing incidence rate trend was observed in 0 to 4 year old boys and girls. Conclusions: This study reports updated incidence and incidence rate trends in children and adolescents diagnosed with type 1 diabetes in Australia. A cyclical pattern in incidence trend persists, with an overall decreasing trend observed only in the youngest age group.
| Original language | English |
|---|---|
| Pages (from-to) | 707-712 |
| Number of pages | 6 |
| Journal | Pediatric Diabetes |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Aug 2020 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors would like to acknowledge James Pearce and Pearl Ng at the Australian Institute for Health and Welfare (NDR, AIHW, Canberra) for their support and assistance with obtaining the relevant approvals and providing the NDR data extract required for this study to be undertaken; Australasian Pediatric Endocrinology Group (APEG) and its members for their contribution in collecting data which is provided to the AIHW NDR from pediatric diabetes registers.
Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
