Increased Anti-saccade Latency Is an Isolated Lingering Abnormality in Sydenham Chorea.

Sheree Cairney, Paul Maruff, J CURRIE, Bart Currie

Research output: Contribution to journalArticlepeer-review


Sydenham chorea (SC) is an autoimmune response to group A beta-hemolytic streptococcal infection whose clinical and imaging manifestations usually resolve within 6 months. We used ocular motor analysis and neuropsychologic assessment to investigate residual striatal dysfunction in two individuals with histories of childhood SC whose most recent episodes of chorea had occurred 5 and 17 years before testing. Compared with the performance of 33 age-matched control subjects, both SC subjects showed significantly increased anti-saccade latencies. These findings support recent theories that acute episodes of SC may cause long-term corticostriatal changes in some individuals.
Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalJournal of Neuro-Ophthalmology
Issue number2
Publication statusPublished - 2009

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