Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

Leo Leonardo; Enny Kenangalem; Jeanne R. Poespoprodjo; Rintis Noviyanti; Ric N. Price; Nicholas M. Anstey; Gabriela Minigo; Steven Kho

doi:10.1186/s12936-022-04268-6

Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

Leo Leonardo, Enny Kenangalem, Jeanne R. Poespoprodjo, Rintis Noviyanti, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Steven Kho

Global and Tropical Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.

Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.

Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.

Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.

Original language	English
Article number	255
Pages (from-to)	1-8
Number of pages	8
Journal	Malaria Journal
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12936-022-04268-6
Publication status	Published - Dec 2022

Bibliographical note

Funding Information:
This study was supported by the National Health and Medical Research Council of Australia (project grants 1021198 and 1021121, program grants 1037304 and 1132975, and fellowship to N.M.A. [1135820]). The field work was also funded by Wellcome Trust (Senior Fellowship in Clinical Science 091625 to R.N.P. and Training Fellowship 062058 to J.R.P.).

Publisher Copyright:
© 2022, The Author(s).

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10.1186/s12936-022-04268-6

Leonardo_MDSC_accepted manuscriptAccepted author manuscript, 445 KBLicence: CC BY
59655971-oaFinal published version, 1.9 MBLicence: CC BY

Cite this

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abstract = "Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.",

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author = "Leo Leonardo and Enny Kenangalem and Poespoprodjo, {Jeanne R.} and Rintis Noviyanti and Price, {Ric N.} and Anstey, {Nicholas M.} and Gabriela Minigo and Steven Kho",

note = "Funding Information: This study was supported by the National Health and Medical Research Council of Australia (project grants 1021198 and 1021121, program grants 1037304 and 1132975, and fellowship to N.M.A. [1135820]). The field work was also funded by Wellcome Trust (Senior Fellowship in Clinical Science 091625 to R.N.P. and Training Fellowship 062058 to J.R.P.). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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doi = "10.1186/s12936-022-04268-6",

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T1 - Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

AU - Leonardo, Leo

AU - Kenangalem, Enny

AU - Poespoprodjo, Jeanne R.

AU - Noviyanti, Rintis

AU - Price, Ric N.

AU - Anstey, Nicholas M.

AU - Minigo, Gabriela

AU - Kho, Steven

N1 - Funding Information: This study was supported by the National Health and Medical Research Council of Australia (project grants 1021198 and 1021121, program grants 1037304 and 1132975, and fellowship to N.M.A. [1135820]). The field work was also funded by Wellcome Trust (Senior Fellowship in Clinical Science 091625 to R.N.P. and Training Fellowship 062058 to J.R.P.). Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.

AB - Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.

KW - Clinical

KW - Malaria

KW - MDSC

KW - Severe falciparum

KW - Vivax

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Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

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