Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

Leo Leonardo, Enny Kenangalem, Jeanne R. Poespoprodjo, Rintis Noviyanti, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Steven Kho

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Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. 

Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. 

Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. 

Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.

Original languageEnglish
Article number255
Pages (from-to)1-8
Number of pages8
JournalMalaria Journal
Issue number1
Publication statusPublished - Dec 2022

Bibliographical note

Funding Information:
This study was supported by the National Health and Medical Research Council of Australia (project grants 1021198 and 1021121, program grants 1037304 and 1132975, and fellowship to N.M.A. [1135820]). The field work was also funded by Wellcome Trust (Senior Fellowship in Clinical Science 091625 to R.N.P. and Training Fellowship 062058 to J.R.P.).

Publisher Copyright:
© 2022, The Author(s).


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