Individualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia

MUHAMMAD REDZWAN S. RASHID ALI, Anna Ralph, Kunji Kannan Sivaraman Kannan, Timothy William

    Research output: Contribution to journalComment/debateResearch

    Abstract

    Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-burden settings, the importance of obtaining upfront culture and susceptibility results in all new TB cases, the problem of acquired drug resistance developing during MDR-TB treatment, the challenges associated with XDR-TB treatment regimens, the value of surgical resection in refractory cases, and the major quality of life impact this disease can have on young, economically productive individuals.
    Original languageEnglish
    Pages (from-to)200-204
    Number of pages5
    JournalMedical Journal of Malaysia
    Volume70
    Issue number3
    Publication statusPublished - 2015

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    Extensively Drug-Resistant Tuberculosis
    Malaysia
    Pulmonary Tuberculosis
    Delivery of Health Care
    Therapeutics
    Drug Resistance
    Quality of Life

    Cite this

    ALI, MUHAMMAD REDZWAN S. RASHID ; Ralph, Anna ; Kannan, Kunji Kannan Sivaraman ; William, Timothy. / Individualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia. In: Medical Journal of Malaysia. 2015 ; Vol. 70, No. 3. pp. 200-204.
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    abstract = "Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-burden settings, the importance of obtaining upfront culture and susceptibility results in all new TB cases, the problem of acquired drug resistance developing during MDR-TB treatment, the challenges associated with XDR-TB treatment regimens, the value of surgical resection in refractory cases, and the major quality of life impact this disease can have on young, economically productive individuals.",
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    Individualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia. / ALI, MUHAMMAD REDZWAN S. RASHID; Ralph, Anna; Kannan, Kunji Kannan Sivaraman; William, Timothy.

    In: Medical Journal of Malaysia, Vol. 70, No. 3, 2015, p. 200-204.

    Research output: Contribution to journalComment/debateResearch

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