Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

Craig Steven Boutlis; M. R. Hobbs; RL Marsh; M. A. Misukonis; A. N. Tkachuk; M. Lagog; J. Booth; D. L. Granger; M. J. Bockarie; C. S. Mgone; M. C. Levesque; J. B. Weinberg; Nicholas Anstey

Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

Craig Steven Boutlis, M. R. Hobbs, RL Marsh, M. A. Misukonis, A. N. Tkachuk, M. Lagog, J. Booth, D. L. Granger, M. J. Bockarie, C. S. Mgone, M. C. Levesque, J. B. Weinberg, Nicholas Anstey

Research output: Contribution to journal › Comment/debate

Abstract

Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G--

Original language	English
Pages (from-to)	569-573
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	69
Issue number	6
Publication status	Published - 2003

Cite this

Boutlis, C. S., Hobbs, M. R., Marsh, RL., Misukonis, M. A., Tkachuk, A. N., Lagog, M., Booth, J., Granger, D. L., Bockarie, M. J., Mgone, C. S., Levesque, M. C., Weinberg, J. B., & Anstey, N. (2003). Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. American Journal of Tropical Medicine and Hygiene, 69(6), 569-573.

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title = "Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population",

abstract = "Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G--",

keywords = "Australia, nitric oxide, Papua New Guinea, Polymorphism,Genetic",

author = "Boutlis, {Craig Steven} and Hobbs, {M. R.} and RL Marsh and Misukonis, {M. A.} and Tkachuk, {A. N.} and M. Lagog and J. Booth and Granger, {D. L.} and Bockarie, {M. J.} and Mgone, {C. S.} and Levesque, {M. C.} and Weinberg, {J. B.} and Nicholas Anstey",

year = "2003",

language = "English",

volume = "69",

pages = "569--573",

journal = "The American Journal of Tropical Medicine and Hygiene ",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "6",

}

Boutlis, CS, Hobbs, MR, Marsh, RL, Misukonis, MA, Tkachuk, AN, Lagog, M, Booth, J, Granger, DL, Bockarie, MJ, Mgone, CS, Levesque, MC, Weinberg, JB & Anstey, N 2003, 'Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population', American Journal of Tropical Medicine and Hygiene, vol. 69, no. 6, pp. 569-573.

Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism : relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. / Boutlis, Craig Steven; Hobbs, M. R.; Marsh, RL et al.

In: American Journal of Tropical Medicine and Hygiene, Vol. 69, No. 6, 2003, p. 569-573.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism

T2 - relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

AU - Boutlis, Craig Steven

AU - Hobbs, M. R.

AU - Marsh, RL

AU - Misukonis, M. A.

AU - Tkachuk, A. N.

AU - Lagog, M.

AU - Booth, J.

AU - Granger, D. L.

AU - Bockarie, M. J.

AU - Mgone, C. S.

AU - Levesque, M. C.

AU - Weinberg, J. B.

AU - Anstey, Nicholas

PY - 2003

Y1 - 2003

N2 - Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G--

AB - Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G--

KW - Australia

KW - nitric oxide

KW - Papua New Guinea

KW - Polymorphism,Genetic

UR - http://www.ajtmh.org/cgi/content/abstract/69/6/569

M3 - Comment/debate

VL - 69

SP - 569

EP - 573

JO - The American Journal of Tropical Medicine and Hygiene

JF - The American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 6

ER -

Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

Abstract

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