Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

Craig Steven Boutlis, M. R. Hobbs, RL Marsh, M. A. Misukonis, A. N. Tkachuk, M. Lagog, J. Booth, D. L. Granger, M. J. Bockarie, C. S. Mgone, M. C. Levesque, J. B. Weinberg, Nicholas Anstey

    Research output: Contribution to journalComment/debate

    Abstract

    Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G--
    Original languageEnglish
    Pages (from-to)569-573
    Number of pages5
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume69
    Issue number6
    Publication statusPublished - 2003

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