Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

M DAVIES, T Tran, D McMillan, D Gardiner, Bart Currie, K Sriprakash

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetically closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions. � 2005 Elsevier SAS. All rights reserved.
Original languageEnglish
Pages (from-to)1128-1138
Number of pages11
JournalMicrobes and Infection
Volume7
Issue number9-10
Publication statusPublished - 2005

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Endemic Diseases
Streptococcus
Epidemiology
Genetic Crosses
Interspersed Repetitive Sequences
Horizontal Gene Transfer
Streptococcus agalactiae
Bacteriophages
Genes
Sequence Analysis

Cite this

DAVIES, M., Tran, T., McMillan, D., Gardiner, D., Currie, B., & Sriprakash, K. (2005). Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions. Microbes and Infection, 7(9-10), 1128-1138.
DAVIES, M ; Tran, T ; McMillan, D ; Gardiner, D ; Currie, Bart ; Sriprakash, K. / Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions. In: Microbes and Infection. 2005 ; Vol. 7, No. 9-10. pp. 1128-1138.
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DAVIES, M, Tran, T, McMillan, D, Gardiner, D, Currie, B & Sriprakash, K 2005, 'Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions' Microbes and Infection, vol. 7, no. 9-10, pp. 1128-1138.

Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions. / DAVIES, M; Tran, T; McMillan, D; Gardiner, D; Currie, Bart; Sriprakash, K.

In: Microbes and Infection, Vol. 7, No. 9-10, 2005, p. 1128-1138.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

AU - DAVIES, M

AU - Tran, T

AU - McMillan, D

AU - Gardiner, D

AU - Currie, Bart

AU - Sriprakash, K

PY - 2005

Y1 - 2005

N2 - Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetically closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions. � 2005 Elsevier SAS. All rights reserved.

AB - Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetically closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions. � 2005 Elsevier SAS. All rights reserved.

KW - article

KW - bacterial flora

KW - bacterial genetics

KW - bacterial strain

KW - bacteriophage

KW - bacterium isolate

KW - controlled study

KW - endemic disease

KW - gene sequence

KW - genetic analysis

KW - genetic cross

KW - genetic epidemiology

KW - genetic trait

KW - genome analysis

KW - geographic distribution

KW - horizontal gene transfer

KW - molecular phylogeny

KW - nonhuman

KW - pathotype

KW - priority journal

KW - species comparison

KW - species endemicity

KW - Streptococcus agalactiae

KW - Streptococcus infection

KW - transposon

KW - Adolescent

KW - Bacteriophages

KW - DNA Transposable Elements

KW - DNA, Bacterial

KW - Endemic Diseases

KW - Epidemiology, Molecular

KW - Gene Transfer, Horizontal

KW - Genes, Bacterial

KW - Genome, Bacterial

KW - Humans

KW - Male

KW - Nucleic Acid Hybridization

KW - Streptococcal Infections

KW - Streptococcus

KW - Streptococcus pyogenes

KW - Streptococcus dysgalactiae

KW - Streptococcus dysgalactiae subsp. equisimilis

KW - Streptococcus sp. 'group A'

KW - Streptococcus sp. 'group B'

KW - Streptococcus sp. 'group G'

M3 - Article

VL - 7

SP - 1128

EP - 1138

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 9-10

ER -