Intestinal proteases of free-living and parasitic astigmatid mites

Deborah C. Holt, Stewart T G Burgess, Simone L. Reynolds, Wajahat Mahmood, Katja Fischer

    Research output: Contribution to journalReview articleResearchpeer-review

    Abstract

    Among arthropod pests, mites are responsible for considerable damage to crops, humans and other animals. However, detailed physiological data on these organisms remain sparse, mainly because of their small size but possibly also because of their extreme diversity. Focusing on intestinal proteases, we draw together information from three distinct mite species that all feed on skin but have separately adapted to a free-living, a strictly ecto-parasitic and a parasitic lifestyle. A wide range of studies involving immunohistology, molecular biology, X-ray crystallography and enzyme biochemistry of mite gut proteases suggests that these creatures have diverged considerably as house dust mites, sheep scab mites and scabies mites. Each species has evolved a particular variation of a presumably ancestral repertoire of digestive enzymes that have become specifically adapted to their individual environmental requirements. 

    Original languageEnglish
    Pages (from-to)339-352
    Number of pages14
    JournalCell and Tissue Research
    Volume351
    Issue number2
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Mites
    Peptide Hydrolases
    Psoroptidae
    Scabies
    Pyroglyphidae
    Arthropods
    X Ray Crystallography
    Enzymes
    Biochemistry
    Life Style
    Molecular Biology
    Skin

    Cite this

    Holt, D. C., Burgess, S. T. G., Reynolds, S. L., Mahmood, W., & Fischer, K. (2013). Intestinal proteases of free-living and parasitic astigmatid mites. Cell and Tissue Research, 351(2), 339-352. https://doi.org/10.1007/s00441-012-1369-9
    Holt, Deborah C. ; Burgess, Stewart T G ; Reynolds, Simone L. ; Mahmood, Wajahat ; Fischer, Katja. / Intestinal proteases of free-living and parasitic astigmatid mites. In: Cell and Tissue Research. 2013 ; Vol. 351, No. 2. pp. 339-352.
    @article{413861006e554b0b8479cfe3d491e6d4,
    title = "Intestinal proteases of free-living and parasitic astigmatid mites",
    abstract = "Among arthropod pests, mites are responsible for considerable damage to crops, humans and other animals. However, detailed physiological data on these organisms remain sparse, mainly because of their small size but possibly also because of their extreme diversity. Focusing on intestinal proteases, we draw together information from three distinct mite species that all feed on skin but have separately adapted to a free-living, a strictly ecto-parasitic and a parasitic lifestyle. A wide range of studies involving immunohistology, molecular biology, X-ray crystallography and enzyme biochemistry of mite gut proteases suggests that these creatures have diverged considerably as house dust mites, sheep scab mites and scabies mites. Each species has evolved a particular variation of a presumably ancestral repertoire of digestive enzymes that have become specifically adapted to their individual environmental requirements. ",
    keywords = "allergen, aspartic proteinase, intestinal protease, intestine enzyme, unclassified drug, allergy, clinical feature, Dermatophagoides pteronyssinus, disease course, enzyme mechanism, epidermis, gene sequence, genome size, host pathogen interaction, human, nonhuman, parasite identification, parasite transmission, priority journal, Psoroptes ovis, psoroptic mange, review, Sarcoptes scabiei, scabies, skin epithelium, X ray crystallography, animal, enzymology, intestine, intestine infection, mite, parasitology, Psoroptidae, Pyroglyphidae, Animals, Humans, Intestinal Diseases, Parasitic, Intestines, Mites, Scabies",
    author = "Holt, {Deborah C.} and Burgess, {Stewart T G} and Reynolds, {Simone L.} and Wajahat Mahmood and Katja Fischer",
    year = "2013",
    doi = "10.1007/s00441-012-1369-9",
    language = "English",
    volume = "351",
    pages = "339--352",
    journal = "Cell and Tissue Research",
    issn = "0302-766X",
    publisher = "Springer",
    number = "2",

    }

    Holt, DC, Burgess, STG, Reynolds, SL, Mahmood, W & Fischer, K 2013, 'Intestinal proteases of free-living and parasitic astigmatid mites', Cell and Tissue Research, vol. 351, no. 2, pp. 339-352. https://doi.org/10.1007/s00441-012-1369-9

    Intestinal proteases of free-living and parasitic astigmatid mites. / Holt, Deborah C.; Burgess, Stewart T G; Reynolds, Simone L.; Mahmood, Wajahat; Fischer, Katja.

    In: Cell and Tissue Research, Vol. 351, No. 2, 2013, p. 339-352.

    Research output: Contribution to journalReview articleResearchpeer-review

    TY - JOUR

    T1 - Intestinal proteases of free-living and parasitic astigmatid mites

    AU - Holt, Deborah C.

    AU - Burgess, Stewart T G

    AU - Reynolds, Simone L.

    AU - Mahmood, Wajahat

    AU - Fischer, Katja

    PY - 2013

    Y1 - 2013

    N2 - Among arthropod pests, mites are responsible for considerable damage to crops, humans and other animals. However, detailed physiological data on these organisms remain sparse, mainly because of their small size but possibly also because of their extreme diversity. Focusing on intestinal proteases, we draw together information from three distinct mite species that all feed on skin but have separately adapted to a free-living, a strictly ecto-parasitic and a parasitic lifestyle. A wide range of studies involving immunohistology, molecular biology, X-ray crystallography and enzyme biochemistry of mite gut proteases suggests that these creatures have diverged considerably as house dust mites, sheep scab mites and scabies mites. Each species has evolved a particular variation of a presumably ancestral repertoire of digestive enzymes that have become specifically adapted to their individual environmental requirements. 

    AB - Among arthropod pests, mites are responsible for considerable damage to crops, humans and other animals. However, detailed physiological data on these organisms remain sparse, mainly because of their small size but possibly also because of their extreme diversity. Focusing on intestinal proteases, we draw together information from three distinct mite species that all feed on skin but have separately adapted to a free-living, a strictly ecto-parasitic and a parasitic lifestyle. A wide range of studies involving immunohistology, molecular biology, X-ray crystallography and enzyme biochemistry of mite gut proteases suggests that these creatures have diverged considerably as house dust mites, sheep scab mites and scabies mites. Each species has evolved a particular variation of a presumably ancestral repertoire of digestive enzymes that have become specifically adapted to their individual environmental requirements. 

    KW - allergen

    KW - aspartic proteinase

    KW - intestinal protease

    KW - intestine enzyme

    KW - unclassified drug

    KW - allergy

    KW - clinical feature

    KW - Dermatophagoides pteronyssinus

    KW - disease course

    KW - enzyme mechanism

    KW - epidermis

    KW - gene sequence

    KW - genome size

    KW - host pathogen interaction

    KW - human

    KW - nonhuman

    KW - parasite identification

    KW - parasite transmission

    KW - priority journal

    KW - Psoroptes ovis

    KW - psoroptic mange

    KW - review

    KW - Sarcoptes scabiei

    KW - scabies

    KW - skin epithelium

    KW - X ray crystallography

    KW - animal

    KW - enzymology

    KW - intestine

    KW - intestine infection

    KW - mite

    KW - parasitology

    KW - Psoroptidae

    KW - Pyroglyphidae

    KW - Animals

    KW - Humans

    KW - Intestinal Diseases, Parasitic

    KW - Intestines

    KW - Mites

    KW - Scabies

    UR - http://www.scopus.com/inward/record.url?scp=84891376892&partnerID=8YFLogxK

    U2 - 10.1007/s00441-012-1369-9

    DO - 10.1007/s00441-012-1369-9

    M3 - Review article

    VL - 351

    SP - 339

    EP - 352

    JO - Cell and Tissue Research

    JF - Cell and Tissue Research

    SN - 0302-766X

    IS - 2

    ER -