Intranasal Vaccination with Streptococcal Fibronectin Binding Protein Sfb1 Fails To Prevent Growth and Dissemination of Streptococcus pyogenes in a Murine Skin Infection Model

J McArthur, E Medina, A Mueller, Johnny Ching, Bart Currie, K Sriprakash, S Talay, G CHHATWAL, M Walker

    Research output: Contribution to journalArticle

    Abstract

    Fibronectin binding protein F1 (Sfb1) of Streptococcus pyogenes (group A streptococcus [GAS]) is a well-characterized adhesin that has been shown to induce protection in mice against a lethal intranasal GAS challenge after intranasal immunization with cholera toxin B subunit (CTB) as adjuvant. With a murine skin infection model, we have shown that Sfb1/CTB vaccination neither elicits opsonizing antibodies nor prevents systemic bacterial growth and dissemination to internal organs after a subcutaneous GAS challenge. These results indicate that an Sfb1-based vaccine should be complemented with additional protective antigens in order to be used in areas such as the tropical north of Australia, where the skin is the primary route of entry for invasive Streptococcal diseases.
    Original languageEnglish
    Pages (from-to)7342-7345
    Number of pages4
    JournalInfection and Immunity
    Volume72
    Issue number12
    Publication statusPublished - 2004

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