@article{15efd8761d074b288d0d05e34aeeff81,
title = "Intranasal Vaccination with Streptococcal Fibronectin Binding Protein Sfb1 Fails To Prevent Growth and Dissemination of Streptococcus pyogenes in a Murine Skin Infection Model",
abstract = "Fibronectin binding protein F1 (Sfb1) of Streptococcus pyogenes (group A streptococcus [GAS]) is a well-characterized adhesin that has been shown to induce protection in mice against a lethal intranasal GAS challenge after intranasal immunization with cholera toxin B subunit (CTB) as adjuvant. With a murine skin infection model, we have shown that Sfb1/CTB vaccination neither elicits opsonizing antibodies nor prevents systemic bacterial growth and dissemination to internal organs after a subcutaneous GAS challenge. These results indicate that an Sfb1-based vaccine should be complemented with additional protective antigens in order to be used in areas such as the tropical north of Australia, where the skin is the primary route of entry for invasive Streptococcal diseases.",
keywords = "adhesin, cholera toxin B subunit, fibronectin binding protein, fibronectin binding protein F1, immunological adjuvant, monoclonal antibody, unclassified drug, animal experiment, animal model, article, Australia, bacterial colonization, bacterial growth, colony forming unit, controlled study, drug efficacy, immune response, mouse, nonhuman, priority journal, skin infection, Streptococcus group A, Streptococcus infection, Streptococcus pyogenes, time series analysis, treatment failure, vaccination, Adhesins, Bacterial, Administration, Intranasal, Animals, Antibodies, Bacterial, Blood Bactericidal Activity, Disease Models, Animal, Mice, Mice, Inbred BALB C, Skin Diseases, Bacterial, Streptococcal Infections, Vaccination",
author = "J McArthur and E Medina and A Mueller and Johnny Ching and Bart Currie and K Sriprakash and S Talay and G CHHATWAL and M Walker",
year = "2004",
language = "English",
volume = "72",
pages = "7342--7345",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "12",
}