Invasive group A Streptococcus disease in Australian children

2016 to 2018 - A descriptive cohort study

Jane Oliver, Elise Thielemans, Alissa McMinn, Ciara Baker, Philip N. Britton, Julia E. Clark, Helen S. Marshall, Christopher C. Blyth, Joshua Francis, Jim Buttery, Andrew C. Steer, Nigel W. Crawford

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Objectives: Invasive group A Streptococcus (iGAS) disease is serious and sometimes life-threatening. The Paediatric Active Enhanced Disease Surveillance (PAEDS) Network collects voluntary notifications from seven major Australian paediatric hospitals on patients with certain conditions, including iGAS disease. Our aims were to: 1) Describe the epidemiological distribution of paediatric iGAS disease in Australia and correlate this with influenza notifications, 2) Identify GAS strains commonly associated with invasive disease in children. 

    Methods: IGAS and influenza notification data were obtained (from the PAEDS Network and the Australian Institute of Health and Welfare, respectively, for the period 1 July 2016 to 30 June 2018). Included iGAS patients had GAS isolated from a normally sterile body site. Data were described according to selected clinical and demographic characteristics, including by age group and Australian State, with proportions and minimum incidence rates estimated. 

    Results: A total of 181 patients were identified, with most (115, 63.5%) <5 years old. The mean annual minimum incidence rate was 1.6 (95% confidence interval: 1.1-2.3) per 100,000 children across the study period. An epidemiological correlation with the seasonal burden of influenza was noted. Contact prophylaxis was not consistently offered. Of 96 patients with emm-typing results available, 72.9% showed emm-1,-4 or-12. 

    Conclusions: Robust surveillance systems and cohesive patient management guidelines are needed. Making iGAS disease nationally notifiable would help facilitate this. Influenza vaccination may contribute to reducing seasonal increases in iGAS incidence. The burden of disease emphasises the need for ongoing progress in GAS vaccine development.

    Original languageEnglish
    Article number1750
    Pages (from-to)1-10
    Number of pages10
    JournalBMC Public Health
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 30 Dec 2019

    Fingerprint

    Streptococcus
    Cohort Studies
    Human Influenza
    Pediatrics
    Incidence
    Pediatric Hospitals
    Vaccination
    Vaccines
    Age Groups
    Demography
    Guidelines
    Confidence Intervals
    Health

    Cite this

    Oliver, J., Thielemans, E., McMinn, A., Baker, C., Britton, P. N., Clark, J. E., ... Crawford, N. W. (2019). Invasive group A Streptococcus disease in Australian children: 2016 to 2018 - A descriptive cohort study. BMC Public Health, 19(1), 1-10. [1750]. https://doi.org/10.1186/s12889-019-8085-2
    Oliver, Jane ; Thielemans, Elise ; McMinn, Alissa ; Baker, Ciara ; Britton, Philip N. ; Clark, Julia E. ; Marshall, Helen S. ; Blyth, Christopher C. ; Francis, Joshua ; Buttery, Jim ; Steer, Andrew C. ; Crawford, Nigel W. / Invasive group A Streptococcus disease in Australian children : 2016 to 2018 - A descriptive cohort study. In: BMC Public Health. 2019 ; Vol. 19, No. 1. pp. 1-10.
    @article{6df5daf6b43d441492ef7344ea596fd0,
    title = "Invasive group A Streptococcus disease in Australian children: 2016 to 2018 - A descriptive cohort study",
    abstract = "Objectives: Invasive group A Streptococcus (iGAS) disease is serious and sometimes life-threatening. The Paediatric Active Enhanced Disease Surveillance (PAEDS) Network collects voluntary notifications from seven major Australian paediatric hospitals on patients with certain conditions, including iGAS disease. Our aims were to: 1) Describe the epidemiological distribution of paediatric iGAS disease in Australia and correlate this with influenza notifications, 2) Identify GAS strains commonly associated with invasive disease in children. Methods: IGAS and influenza notification data were obtained (from the PAEDS Network and the Australian Institute of Health and Welfare, respectively, for the period 1 July 2016 to 30 June 2018). Included iGAS patients had GAS isolated from a normally sterile body site. Data were described according to selected clinical and demographic characteristics, including by age group and Australian State, with proportions and minimum incidence rates estimated. Results: A total of 181 patients were identified, with most (115, 63.5{\%}) <5 years old. The mean annual minimum incidence rate was 1.6 (95{\%} confidence interval: 1.1-2.3) per 100,000 children across the study period. An epidemiological correlation with the seasonal burden of influenza was noted. Contact prophylaxis was not consistently offered. Of 96 patients with emm-typing results available, 72.9{\%} showed emm-1,-4 or-12. Conclusions: Robust surveillance systems and cohesive patient management guidelines are needed. Making iGAS disease nationally notifiable would help facilitate this. Influenza vaccination may contribute to reducing seasonal increases in iGAS incidence. The burden of disease emphasises the need for ongoing progress in GAS vaccine development.",
    keywords = "Child health, Group A Streptococcus, Infectious diseases, Invasive, Public health",
    author = "Jane Oliver and Elise Thielemans and Alissa McMinn and Ciara Baker and Britton, {Philip N.} and Clark, {Julia E.} and Marshall, {Helen S.} and Blyth, {Christopher C.} and Joshua Francis and Jim Buttery and Steer, {Andrew C.} and Crawford, {Nigel W.}",
    year = "2019",
    month = "12",
    day = "30",
    doi = "10.1186/s12889-019-8085-2",
    language = "English",
    volume = "19",
    pages = "1--10",
    journal = "BMC Public Health",
    issn = "1471-2458",
    publisher = "BioMed Central",
    number = "1",

    }

    Oliver, J, Thielemans, E, McMinn, A, Baker, C, Britton, PN, Clark, JE, Marshall, HS, Blyth, CC, Francis, J, Buttery, J, Steer, AC & Crawford, NW 2019, 'Invasive group A Streptococcus disease in Australian children: 2016 to 2018 - A descriptive cohort study', BMC Public Health, vol. 19, no. 1, 1750, pp. 1-10. https://doi.org/10.1186/s12889-019-8085-2

    Invasive group A Streptococcus disease in Australian children : 2016 to 2018 - A descriptive cohort study. / Oliver, Jane; Thielemans, Elise; McMinn, Alissa; Baker, Ciara; Britton, Philip N.; Clark, Julia E.; Marshall, Helen S.; Blyth, Christopher C.; Francis, Joshua; Buttery, Jim; Steer, Andrew C.; Crawford, Nigel W.

    In: BMC Public Health, Vol. 19, No. 1, 1750, 30.12.2019, p. 1-10.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Invasive group A Streptococcus disease in Australian children

    T2 - 2016 to 2018 - A descriptive cohort study

    AU - Oliver, Jane

    AU - Thielemans, Elise

    AU - McMinn, Alissa

    AU - Baker, Ciara

    AU - Britton, Philip N.

    AU - Clark, Julia E.

    AU - Marshall, Helen S.

    AU - Blyth, Christopher C.

    AU - Francis, Joshua

    AU - Buttery, Jim

    AU - Steer, Andrew C.

    AU - Crawford, Nigel W.

    PY - 2019/12/30

    Y1 - 2019/12/30

    N2 - Objectives: Invasive group A Streptococcus (iGAS) disease is serious and sometimes life-threatening. The Paediatric Active Enhanced Disease Surveillance (PAEDS) Network collects voluntary notifications from seven major Australian paediatric hospitals on patients with certain conditions, including iGAS disease. Our aims were to: 1) Describe the epidemiological distribution of paediatric iGAS disease in Australia and correlate this with influenza notifications, 2) Identify GAS strains commonly associated with invasive disease in children. Methods: IGAS and influenza notification data were obtained (from the PAEDS Network and the Australian Institute of Health and Welfare, respectively, for the period 1 July 2016 to 30 June 2018). Included iGAS patients had GAS isolated from a normally sterile body site. Data were described according to selected clinical and demographic characteristics, including by age group and Australian State, with proportions and minimum incidence rates estimated. Results: A total of 181 patients were identified, with most (115, 63.5%) <5 years old. The mean annual minimum incidence rate was 1.6 (95% confidence interval: 1.1-2.3) per 100,000 children across the study period. An epidemiological correlation with the seasonal burden of influenza was noted. Contact prophylaxis was not consistently offered. Of 96 patients with emm-typing results available, 72.9% showed emm-1,-4 or-12. Conclusions: Robust surveillance systems and cohesive patient management guidelines are needed. Making iGAS disease nationally notifiable would help facilitate this. Influenza vaccination may contribute to reducing seasonal increases in iGAS incidence. The burden of disease emphasises the need for ongoing progress in GAS vaccine development.

    AB - Objectives: Invasive group A Streptococcus (iGAS) disease is serious and sometimes life-threatening. The Paediatric Active Enhanced Disease Surveillance (PAEDS) Network collects voluntary notifications from seven major Australian paediatric hospitals on patients with certain conditions, including iGAS disease. Our aims were to: 1) Describe the epidemiological distribution of paediatric iGAS disease in Australia and correlate this with influenza notifications, 2) Identify GAS strains commonly associated with invasive disease in children. Methods: IGAS and influenza notification data were obtained (from the PAEDS Network and the Australian Institute of Health and Welfare, respectively, for the period 1 July 2016 to 30 June 2018). Included iGAS patients had GAS isolated from a normally sterile body site. Data were described according to selected clinical and demographic characteristics, including by age group and Australian State, with proportions and minimum incidence rates estimated. Results: A total of 181 patients were identified, with most (115, 63.5%) <5 years old. The mean annual minimum incidence rate was 1.6 (95% confidence interval: 1.1-2.3) per 100,000 children across the study period. An epidemiological correlation with the seasonal burden of influenza was noted. Contact prophylaxis was not consistently offered. Of 96 patients with emm-typing results available, 72.9% showed emm-1,-4 or-12. Conclusions: Robust surveillance systems and cohesive patient management guidelines are needed. Making iGAS disease nationally notifiable would help facilitate this. Influenza vaccination may contribute to reducing seasonal increases in iGAS incidence. The burden of disease emphasises the need for ongoing progress in GAS vaccine development.

    KW - Child health

    KW - Group A Streptococcus

    KW - Infectious diseases

    KW - Invasive

    KW - Public health

    UR - http://www.scopus.com/inward/record.url?scp=85077340431&partnerID=8YFLogxK

    U2 - 10.1186/s12889-019-8085-2

    DO - 10.1186/s12889-019-8085-2

    M3 - Article

    VL - 19

    SP - 1

    EP - 10

    JO - BMC Public Health

    JF - BMC Public Health

    SN - 1471-2458

    IS - 1

    M1 - 1750

    ER -