Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Rhea J. Longley; Matthew J. Grigg; Kael Schoffer; Thomas Obadia; Stephanie Hyslop; Kim A. Piera; Narimane Nekkab; Ramin Mazhari; Eizo Takashima; Takafumi Tsuboi; Matthias Harbers; Kevin Tetteh; Chris Drakeley; Chetan E. Chitnis; Julie Healer; Wai Hong Tham; Jetsumon Sattabongkot; Michael T. White; Daniel J. Cooper; Giri S. Rajahram; Bridget E. Barber; Timothy William; Nicholas M. Anstey; Ivo Mueller

doi:10.1016/j.xcrm.2022.100662

Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Rhea J. Longley, Matthew J. Grigg, Kael Schoffer, Thomas Obadia, Stephanie Hyslop, Kim A. Piera, Narimane Nekkab, Ramin Mazhari, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Kevin Tetteh, Chris Drakeley, Chetan E. Chitnis, Julie Healer, Wai Hong Tham, Jetsumon Sattabongkot, Michael T. White, Daniel J. Cooper, Giri S. RajahramBridget E. Barber, Timothy William, Nicholas M. Anstey, Ivo Mueller

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Abstract

Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.

Original language	English
Article number	100662
Pages (from-to)	1-17
Number of pages	17
Journal	Cell reports. Medicine
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/j.xcrm.2022.100662
Publication status	Published - 21 Jun 2022

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Longley, R. J., Grigg, M. J., Schoffer, K., Obadia, T., Hyslop, S., Piera, K. A., Nekkab, N., Mazhari, R., Takashima, E., Tsuboi, T., Harbers, M., Tetteh, K., Drakeley, C., Chitnis, C. E., Healer, J., Tham, W. H., Sattabongkot, J., White, M. T., Cooper, D. J., ... Mueller, I. (2022). Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi. Cell reports. Medicine, 3(6), 1-17. Article 100662. https://doi.org/10.1016/j.xcrm.2022.100662

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title = "Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi",

abstract = "Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.",

keywords = "antibodies, antibody cross-reactivity, malaria, malaria elimination, Plasmodium knowlesi, Plasmodium vivax, serological exposure markers, serosurveillance, species cross-reactivity",

author = "Longley, {Rhea J.} and Grigg, {Matthew J.} and Kael Schoffer and Thomas Obadia and Stephanie Hyslop and Piera, {Kim A.} and Narimane Nekkab and Ramin Mazhari and Eizo Takashima and Takafumi Tsuboi and Matthias Harbers and Kevin Tetteh and Chris Drakeley and Chitnis, {Chetan E.} and Julie Healer and Tham, {Wai Hong} and Jetsumon Sattabongkot and White, {Michael T.} and Cooper, {Daniel J.} and Rajahram, {Giri S.} and Barber, {Bridget E.} and Timothy William and Anstey, {Nicholas M.} and Ivo Mueller",

year = "2022",

month = jun,

day = "21",

doi = "10.1016/j.xcrm.2022.100662",

language = "English",

volume = "3",

pages = "1--17",

journal = "Cell reports. Medicine",

issn = "2666-3791",

publisher = "Cell Press",

number = "6",

}

Longley, RJ, Grigg, MJ, Schoffer, K, Obadia, T, Hyslop, S, Piera, KA, Nekkab, N, Mazhari, R, Takashima, E, Tsuboi, T, Harbers, M, Tetteh, K, Drakeley, C, Chitnis, CE, Healer, J, Tham, WH, Sattabongkot, J, White, MT, Cooper, DJ, Rajahram, GS, Barber, BE, William, T, Anstey, NM & Mueller, I 2022, 'Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi', Cell reports. Medicine, vol. 3, no. 6, 100662, pp. 1-17. https://doi.org/10.1016/j.xcrm.2022.100662

TY - JOUR

T1 - Plasmodium vivax malaria serological exposure markers

T2 - Assessing the degree and implications of cross-reactivity with P. knowlesi

AU - Longley, Rhea J.

AU - Grigg, Matthew J.

AU - Schoffer, Kael

AU - Obadia, Thomas

AU - Hyslop, Stephanie

AU - Piera, Kim A.

AU - Nekkab, Narimane

AU - Mazhari, Ramin

AU - Takashima, Eizo

AU - Tsuboi, Takafumi

AU - Harbers, Matthias

AU - Tetteh, Kevin

AU - Drakeley, Chris

AU - Chitnis, Chetan E.

AU - Healer, Julie

AU - Tham, Wai Hong

AU - Sattabongkot, Jetsumon

AU - White, Michael T.

AU - Cooper, Daniel J.

AU - Rajahram, Giri S.

AU - Barber, Bridget E.

AU - William, Timothy

AU - Anstey, Nicholas M.

AU - Mueller, Ivo

PY - 2022/6/21

Y1 - 2022/6/21

N2 - Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.

AB - Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.

KW - antibodies

KW - antibody cross-reactivity

KW - malaria

KW - malaria elimination

KW - Plasmodium knowlesi

KW - Plasmodium vivax

KW - serological exposure markers

KW - serosurveillance

KW - species cross-reactivity

UR - http://www.scopus.com/inward/record.url?scp=85132610519&partnerID=8YFLogxK

U2 - 10.1016/j.xcrm.2022.100662

DO - 10.1016/j.xcrm.2022.100662

M3 - Article

C2 - 35732155

AN - SCOPUS:85132610519

SN - 2666-3791

VL - 3

SP - 1

EP - 17

JO - Cell reports. Medicine

JF - Cell reports. Medicine

IS - 6

M1 - 100662

ER -

Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

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